Bedwell DW - Search Results

1

In vitro characterization of the bioconversion of pomaglumetad methionil, a novel metabotropic glutamate 2/3 receptor agonist peptide prodrug.

Moulton RD, Ruterbories KJ, Bedwell DW, Mohutsky MA. Moulton RD, et al. Among authors: bedwell dw. Drug Metab Dispos. 2015 May;43(5):756-61. doi: 10.1124/dmd.114.062893. Epub 2015 Mar 9. Drug Metab Dispos. 2015. PMID: 25755052

2

Ablation of both organic cation transporter (OCT)1 and OCT2 alters metformin pharmacokinetics but has no effect on tissue drug exposure and pharmacodynamics.

Higgins JW, Bedwell DW, Zamek-Gliszczynski MJ. Higgins JW, et al. Among authors: bedwell dw. Drug Metab Dispos. 2012 Jun;40(6):1170-7. doi: 10.1124/dmd.112.044875. Epub 2012 Mar 9. Drug Metab Dispos. 2012. PMID: 22407892

3

Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics.

Zamek-Gliszczynski MJ, Bedwell DW, Bao JQ, Higgins JW. Zamek-Gliszczynski MJ, et al. Among authors: bedwell dw. Drug Metab Dispos. 2012 Sep;40(9):1825-33. doi: 10.1124/dmd.112.046508. Epub 2012 Jun 18. Drug Metab Dispos. 2012. PMID: 22711747

4

Difference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley Rats.

Zhou X, Rougée LR, Bedwell DW, Cramer JW, Mohutsky MA, Calvert NA, Moulton RD, Cassidy KC, Yumibe NP, Adams LA, Ruterbories KJ. Zhou X, et al. Among authors: bedwell dw. Drug Metab Dispos. 2016 Aug;44(8):1184-92. doi: 10.1124/dmd.116.070623. Epub 2016 May 23. Drug Metab Dispos. 2016. PMID: 27217490

5

The Impact of the Hepatocyte-to-Plasma pH Gradient on the Prediction of Hepatic Clearance and Drug-Drug Interactions for CYP2D6 Substrates.

Rougée LR, Mohutsky MA, Bedwell DW, Ruterbories KJ, Hall SD. Rougée LR, et al. Among authors: bedwell dw. Drug Metab Dispos. 2016 Nov;44(11):1819-1827. doi: 10.1124/dmd.116.071761. Epub 2016 Sep 2. Drug Metab Dispos. 2016. PMID: 27590024

6

Novel bicyclo[3.1.0]hexane analogs as antagonists of metabotropic glutamate 2/3 receptors for the treatment of depression.

Dressman BA, Tromiczak EG, Chappell MD, Tripp AE, Quimby SJ, Vetman T, Fivush AM, Matt J, Jaramillo C, Li R, Khilevich A, Blanco MJ, Smith SC, Carpintero M, de Diego JE, Barberis M, García-Cerrada S, Soriano JF, Schkeryantz JM, Witkin JM, Wafford KA, Seidel W, Britton T, Overshiner CD, Li X, Wang XS, Heinz BA, Catlow JT, Swanson S, Bedwell D, Ornstein PL, Mitch CH. Dressman BA, et al. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5663-5668. doi: 10.1016/j.bmcl.2016.10.067. Epub 2016 Oct 25. Bioorg Med Chem Lett. 2016. PMID: 27836401

7

The Impact of the Hepatocyte-to-Plasma pH Gradient on the Prediction of Hepatic Clearance and Drug-Drug Interactions for CYP2C9 and CYP3A4 Substrates.

Rougée LRA, Mohutsky MA, Bedwell DW, Ruterbories KJ, Hall SD. Rougée LRA, et al. Among authors: bedwell dw. Drug Metab Dispos. 2017 Sep;45(9):1008-1018. doi: 10.1124/dmd.117.076331. Epub 2017 Jul 5. Drug Metab Dispos. 2017. PMID: 28679672

8

Development of a rapid and sensitive multiple reaction monitoring proteomic approach for quantification of transporters in human liver tissue.

Wang L, Rubadue KJ, Alberts J, Bedwell DW, Ruterbories KJ. Wang L, et al. Among authors: bedwell dw. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Sep 1;1061-1062:356-363. doi: 10.1016/j.jchromb.2017.07.051. Epub 2017 Aug 1. J Chromatogr B Analyt Technol Biomed Life Sci. 2017. PMID: 28800539

9

Hepatic Organic Anion Transporting Polypeptide-Mediated Clearance in the Beagle Dog: Assessing In Vitro-In Vivo Relationships and Applying Cross-Species Empirical Scaling Factors to Improve Prediction of Human Clearance.

Matsunaga N, Ufuk A, Morse BL, Bedwell DW, Bao J, Mohutsky MA, Hillgren KM, Hall SD, Houston JB, Galetin A. Matsunaga N, et al. Among authors: bedwell dw. Drug Metab Dispos. 2019 Mar;47(3):215-226. doi: 10.1124/dmd.118.084194. Epub 2018 Dec 28. Drug Metab Dispos. 2019. PMID: 30593544

10

Impact of Heterotropic Allosteric Modulation on the Time-Dependent Inhibition of Cytochrome P450 3A4.

Rougée LRA, Bedwell DW, Hansen K, Abraham TL, Hall SD. Rougée LRA, et al. Among authors: bedwell dw. Drug Metab Dispos. 2023 Oct;51(10):1372-1380. doi: 10.1124/dmd.123.001382. Epub 2023 Jul 31. Drug Metab Dispos. 2023. PMID: 37524542

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