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Redirecting tropane alkaloid metabolism reveals pyrrolidine alkaloid diversity in Atropa belladonna.
New Phytol. 2023 Mar;237(5):1810-1825. doi: 10.1111/nph.18651. Epub 2022 Dec 18.
New Phytol. 2023.
PMID: 36451537
Free PMC article.
A root-expressed L-phenylalanine:4-hydroxyphenylpyruvate aminotransferase is required for tropane alkaloid biosynthesis in Atropa belladonna.
Bedewitz MA, Góngora-Castillo E, Uebler JB, Gonzales-Vigil E, Wiegert-Rininger KE, Childs KL, Hamilton JP, Vaillancourt B, Yeo YS, Chappell J, DellaPenna D, Jones AD, Buell CR, Barry CS.
Bedewitz MA, et al.
Plant Cell. 2014 Sep;26(9):3745-62. doi: 10.1105/tpc.114.130534. Epub 2014 Sep 16.
Plant Cell. 2014.
PMID: 25228340
Free PMC article.
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Tropinone synthesis via an atypical polyketide synthase and P450-mediated cyclization.
Bedewitz MA, Jones AD, D'Auria JC, Barry CS.
Bedewitz MA, et al.
Nat Commun. 2018 Dec 11;9(1):5281. doi: 10.1038/s41467-018-07671-3.
Nat Commun. 2018.
PMID: 30538251
Free PMC article.
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Metabolomics-guided discovery of cytochrome P450s involved in pseudotropine-dependent biosynthesis of modified tropane alkaloids.
Sadre R, Anthony TM, Grabar JM, Bedewitz MA, Jones AD, Barry CS.
Sadre R, et al. Among authors: bedewitz ma.
Nat Commun. 2022 Jul 2;13(1):3832. doi: 10.1038/s41467-022-31653-1.
Nat Commun. 2022.
PMID: 35780230
Free PMC article.
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An Automated Data-Driven Pipeline for Improving Heterologous Enzyme Expression.
Wrenbeck EE, Bedewitz MA, Klesmith JR, Noshin S, Barry CS, Whitehead TA.
Wrenbeck EE, et al. Among authors: bedewitz ma.
ACS Synth Biol. 2019 Mar 15;8(3):474-481. doi: 10.1021/acssynbio.8b00486. Epub 2019 Feb 8.
ACS Synth Biol. 2019.
PMID: 30721031
Free PMC article.
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Rapid biosensor development using plant hormone receptors as reprogrammable scaffolds.
Beltrán J, Steiner PJ, Bedewitz M, Wei S, Peterson FC, Li Z, Hughes BE, Hartley Z, Robertson NR, Medina-Cucurella AV, Baumer ZT, Leonard AC, Park SY, Volkman BF, Nusinow DA, Zhong W, Wheeldon I, Cutler SR, Whitehead TA.
Beltrán J, et al.
Nat Biotechnol. 2022 Dec;40(12):1855-1861. doi: 10.1038/s41587-022-01364-5. Epub 2022 Jun 20.
Nat Biotechnol. 2022.
PMID: 35726092
Free PMC article.
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GMMA Can Stabilize Proteins Across Different Functional Constraints.
Daffern N, Johansson KE, Baumer ZT, Robertson NR, Woojuh J, Bedewitz MA, Davis Z, Wheeldon I, Cutler SR, Lindorff-Larsen K, Whitehead TA.
Daffern N, et al. Among authors: bedewitz ma.
J Mol Biol. 2024 Apr 23;436(11):168586. doi: 10.1016/j.jmb.2024.168586. Online ahead of print.
J Mol Biol. 2024.
PMID: 38663544
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