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Dietary lipids fuel GPX4-restricted enteritis resembling Crohn's disease.
Mayr L, Grabherr F, Schwärzler J, Reitmeier I, Sommer F, Gehmacher T, Niederreiter L, He GW, Ruder B, Kunz KTR, Tymoszuk P, Hilbe R, Haschka D, Feistritzer C, Gerner RR, Enrich B, Przysiecki N, Seifert M, Keller MA, Oberhuber G, Sprung S, Ran Q, Koch R, Effenberger M, Tancevski I, Zoller H, Moschen AR, Weiss G, Becker C, Rosenstiel P, Kaser A, Tilg H, Adolph TE. Mayr L, et al. Among authors: becker c. Nat Commun. 2020 Apr 14;11(1):1775. doi: 10.1038/s41467-020-15646-6. Nat Commun. 2020. PMID: 32286299 Free PMC article.
The enhanced susceptibility of ADAM-17 hypomorphic mice to DSS-induced colitis is not ameliorated by loss of RIPK3, revealing an unexpected function of ADAM-17 in necroptosis.
Fuchslocher Chico J, Falk-Paulsen M, Luzius A, Saggau C, Ruder B, Bolik J, Schmidt-Arras D, Linkermann A, Becker C, Rosenstiel P, Rose-John S, Adam D. Fuchslocher Chico J, et al. Among authors: becker c. Oncotarget. 2018 Feb 5;9(16):12941-12958. doi: 10.18632/oncotarget.24410. eCollection 2018 Feb 27. Oncotarget. 2018. PMID: 29560122 Free PMC article.
PGAM5 is a key driver of mitochondrial dysfunction in experimental lung fibrosis.
Ganzleben I, He GW, Günther C, Prigge ES, Richter K, Rieker RJ, Mougiakakos D, Neurath MF, Becker C. Ganzleben I, et al. Among authors: becker c. Cell Mol Life Sci. 2019 Dec;76(23):4783-4794. doi: 10.1007/s00018-019-03133-1. Epub 2019 Jun 5. Cell Mol Life Sci. 2019. PMID: 31168659 Free PMC article.
Interferon Lambda Promotes Paneth Cell Death Via STAT1 Signaling in Mice and Is Increased in Inflamed Ileal Tissues of Patients With Crohn's Disease.
Günther C, Ruder B, Stolzer I, Dorner H, He GW, Chiriac MT, Aden K, Strigli A, Bittel M, Zeissig S, Rosenstiel P, Atreya R, Neurath MF, Wirtz S, Becker C. Günther C, et al. Among authors: becker c. Gastroenterology. 2019 Nov;157(5):1310-1322.e13. doi: 10.1053/j.gastro.2019.07.031. Epub 2019 Jul 25. Gastroenterology. 2019. PMID: 31352002
Viral FLIP blocks Caspase-8 driven apoptosis in the gut in vivo.
Ruder B, Günther C, Stürzl M, Neurath MF, Cesarman E, Ballon G, Becker C. Ruder B, et al. Among authors: becker c. PLoS One. 2020 Jan 30;15(1):e0228441. doi: 10.1371/journal.pone.0228441. eCollection 2020. PLoS One. 2020. PMID: 31999759 Free PMC article.
3,994 results