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The SWI/SNF chromatin-remodeling subunit DPF2 facilitates NRF2-dependent antiinflammatory and antioxidant gene expression.
Mas G, Man N, Nakata Y, Martinez-Caja C, Karl D, Beckedorff F, Tamiro F, Chen C, Duffort S, Itonaga H, Mookhtiar AK, Kunkalla K, Valencia AM, Collings CK, Kadoch C, Vega F, Kogan SC, Shiekhattar R, Morey L, Bilbao D, Nimer SD. Mas G, et al. Among authors: beckedorff f. J Clin Invest. 2023 Jul 3;133(13):e158419. doi: 10.1172/JCI158419. J Clin Invest. 2023. PMID: 37200093 Free PMC article.
Endogenous metabolism in endothelial and immune cells generates most of the tissue vitamin B3 (nicotinamide).
Zeidler JD, Chini CCS, Kanamori KS, Kashyap S, Espindola-Netto JM, Thompson K, Warner G, Cabral FS, Peclat TR, Gomez LS, Lopez SA, Wandersee MK, Schoon RA, Reid K, Menzies K, Beckedorff F, Reid JM, Brachs S, Meyer RG, Meyer-Ficca ML, Chini EN. Zeidler JD, et al. Among authors: beckedorff f. iScience. 2022 Oct 23;25(11):105431. doi: 10.1016/j.isci.2022.105431. eCollection 2022 Nov 18. iScience. 2022. PMID: 36388973 Free PMC article.
The Integrator complex regulates microRNA abundance through RISC loading.
Kirstein N, Dokaneheifard S, Cingaram PR, Valencia MG, Beckedorff F, Gomes Dos Santos H, Blumenthal E, Tayari MM, Gaidosh GS, Shiekhattar R. Kirstein N, et al. Among authors: beckedorff f. Sci Adv. 2023 Feb 10;9(6):eadf0597. doi: 10.1126/sciadv.adf0597. Epub 2023 Feb 10. Sci Adv. 2023. PMID: 36763664 Free PMC article.
Dietary palmitic acid promotes a prometastatic memory via Schwann cells.
Pascual G, Domínguez D, Elosúa-Bayes M, Beckedorff F, Laudanna C, Bigas C, Douillet D, Greco C, Symeonidi A, Hernández I, Gil SR, Prats N, Bescós C, Shiekhattar R, Amit M, Heyn H, Shilatifard A, Benitah SA. Pascual G, et al. Among authors: beckedorff f. Nature. 2021 Nov;599(7885):485-490. doi: 10.1038/s41586-021-04075-0. Epub 2021 Nov 10. Nature. 2021. PMID: 34759321 Free article.
Integrator enforces the fidelity of transcriptional termination at protein-coding genes.
Dasilva LF, Blumenthal E, Beckedorff F, Cingaram PR, Gomes Dos Santos H, Edupuganti RR, Zhang A, Dokaneheifard S, Aoi Y, Yue J, Kirstein N, Tayari MM, Shilatifard A, Shiekhattar R. Dasilva LF, et al. Among authors: beckedorff f. Sci Adv. 2021 Nov 5;7(45):eabe3393. doi: 10.1126/sciadv.abe3393. Epub 2021 Nov 3. Sci Adv. 2021. PMID: 34730992 Free PMC article.
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