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CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression.
Nat Biotechnol. 2008 May;26(5):549-51. doi: 10.1038/nbt1399. Epub 2008 Apr 27.
Nat Biotechnol. 2008.
PMID: 18438402
Free article.
Review.
Strategies for long-term expression of transgenes in the respiratory epithelium.
Gill DR, Bazzani RP, Hyde SC.
Gill DR, et al. Among authors: bazzani rp.
Curr Opin Mol Ther. 2010 Aug;12(4):386-93.
Curr Opin Mol Ther. 2010.
PMID: 20677089
Review.
Item in Clipboard
The significance of plasmid DNA preparations contaminated with bacterial genomic DNA on inflammatory responses following delivery of lipoplexes to the murine lung.
Bazzani RP, Cai Y, Hebel HL, Hyde SC, Gill DR.
Bazzani RP, et al.
Biomaterials. 2011 Dec;32(36):9854-65. doi: 10.1016/j.biomaterials.2011.08.092. Epub 2011 Sep 23.
Biomaterials. 2011.
PMID: 21944469
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The use of CpG-free plasmids to mediate persistent gene expression following repeated aerosol delivery of pDNA/PEI complexes.
Davies LA, Hyde SC, Nunez-Alonso G, Bazzani RP, Harding-Smith R, Pringle IA, Lawton AE, Abdullah S, Roberts TC, McCormick D, Sumner-Jones SG, Gill DR.
Davies LA, et al. Among authors: bazzani rp.
Biomaterials. 2012 Aug;33(22):5618-27. doi: 10.1016/j.biomaterials.2012.04.019. Epub 2012 May 8.
Biomaterials. 2012.
PMID: 22575838
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Transgene sequences free of CG dinucleotides lead to high level, long-term expression in the lung independent of plasmid backbone design.
Bazzani RP, Pringle IA, Connolly MM, Davies LA, Sumner-Jones SG, Schleef M, Hyde SC, Gill DR.
Bazzani RP, et al.
Biomaterials. 2016 Jul;93:20-26. doi: 10.1016/j.biomaterials.2016.03.029. Epub 2016 Mar 22.
Biomaterials. 2016.
PMID: 27061267
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