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The New Antitumor Drug ABTL0812 Inhibits the Akt/mTORC1 Axis by Upregulating Tribbles-3 Pseudokinase.
Erazo T, Lorente M, López-Plana A, Muñoz-Guardiola P, Fernández-Nogueira P, García-Martínez JA, Bragado P, Fuster G, Salazar M, Espadaler J, Hernández-Losa J, Bayascas JR, Cortal M, Vidal L, Gascón P, Gómez-Ferreria M, Alfón J, Velasco G, Domènech C, Lizcano JM. Erazo T, et al. Among authors: bayascas jr. Clin Cancer Res. 2016 May 15;22(10):2508-19. doi: 10.1158/1078-0432.CCR-15-1808. Epub 2015 Dec 15. Clin Cancer Res. 2016. PMID: 26671995 Free article. Clinical Trial.
Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex.
Erazo T, Moreno A, Ruiz-Babot G, Rodríguez-Asiain A, Morrice NA, Espadamala J, Bayascas JR, Gómez N, Lizcano JM. Erazo T, et al. Among authors: bayascas jr. Mol Cell Biol. 2013 Apr;33(8):1671-86. doi: 10.1128/MCB.01246-12. Epub 2013 Feb 19. Mol Cell Biol. 2013. PMID: 23428871 Free PMC article.
Correction for Zurashvili et al., Interaction of PDK1 with Phosphoinositides Is Essential for Neuronal Differentiation but Dispensable for Neuronal Survival.
Zurashvili T, Cordón-Barris L, Ruiz-Babot G, Zhou X, Lizcano JM, Gómez N, Giménez-Llort L, Bayascas JR. Zurashvili T, et al. Among authors: bayascas jr. Mol Cell Biol. 2016 May 31;36(12):1818. doi: 10.1128/MCB.00085-16. Print 2016 Jun 15. Mol Cell Biol. 2016. PMID: 27247313 Free PMC article. No abstract available.
Mutation of the 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Substrate-Docking Site in the Developing Brain Causes Microcephaly with Abnormal Brain Morphogenesis Independently of Akt, Leading to Impaired Cognition and Disruptive Behaviors.
Cordón-Barris L, Pascual-Guiral S, Yang S, Giménez-Llort L, Lope-Piedrafita S, Niemeyer C, Claro E, Lizcano JM, Bayascas JR. Cordón-Barris L, et al. Among authors: bayascas jr. Mol Cell Biol. 2016 Nov 14;36(23):2967-2982. doi: 10.1128/MCB.00230-16. Print 2016 Dec 1. Mol Cell Biol. 2016. PMID: 27644329 Free PMC article.
The ERK5/NF-κB signaling pathway targets endometrial cancer proliferation and survival.
Diéguez-Martínez N, Espinosa-Gil S, Yoldi G, Megías-Roda E, Bolinaga-Ayala I, Viñas-Casas M, Gorgisen G, Domingo-Ortí I, Pérez-Montoyo H, Bayascas JR, Colas E, Dolcet X, Lizcano JM. Diéguez-Martínez N, et al. Among authors: bayascas jr. Cell Mol Life Sci. 2022 Sep 19;79(10):524. doi: 10.1007/s00018-022-04541-6. Cell Mol Life Sci. 2022. PMID: 36123565 Free PMC article.
MicroRNA-497 impairs the growth of chemoresistant neuroblastoma cells by targeting cell cycle, survival and vascular permeability genes.
Soriano A, París-Coderch L, Jubierre L, Martínez A, Zhou X, Piskareva O, Bray I, Vidal I, Almazán-Moga A, Molist C, Roma J, Bayascas JR, Casanovas O, Stallings RL, Sánchez de Toledo J, Gallego S, Segura MF. Soriano A, et al. Among authors: bayascas jr. Oncotarget. 2016 Feb 23;7(8):9271-87. doi: 10.18632/oncotarget.7005. Oncotarget. 2016. PMID: 26824183 Free PMC article.
Effects of CK2β subunit down-regulation on Akt signalling in HK-2 renal cells.
Alcaraz E, Vilardell J, Borgo C, Sarró E, Plana M, Marin O, Pinna LA, Bayascas JR, Meseguer A, Salvi M, Itarte E, Ruzzene M. Alcaraz E, et al. Among authors: bayascas jr. PLoS One. 2020 Jan 7;15(1):e0227340. doi: 10.1371/journal.pone.0227340. eCollection 2020. PLoS One. 2020. PMID: 31910234 Free PMC article.
41 results