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Identification of the Tau phosphorylation pattern that drives its aggregation.
Despres C, Byrne C, Qi H, Cantrelle FX, Huvent I, Chambraud B, Baulieu EE, Jacquot Y, Landrieu I, Lippens G, Smet-Nocca C. Despres C, et al. Among authors: baulieu ee. Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):9080-9085. doi: 10.1073/pnas.1708448114. Epub 2017 Aug 7. Proc Natl Acad Sci U S A. 2017. PMID: 28784767 Free PMC article.
Immunophilin FKBP52 induces Tau-P301L filamentous assembly in vitro and modulates its activity in a model of tauopathy.
Giustiniani J, Chambraud B, Sardin E, Dounane O, Guillemeau K, Nakatani H, Paquet D, Kamah A, Landrieu I, Lippens G, Baulieu EE, Tawk M. Giustiniani J, et al. Among authors: baulieu ee. Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4584-9. doi: 10.1073/pnas.1402645111. Epub 2014 Mar 12. Proc Natl Acad Sci U S A. 2014. PMID: 24623856 Free PMC article.
A role for FKBP52 in Tau protein function.
Chambraud B, Sardin E, Giustiniani J, Dounane O, Schumacher M, Goedert M, Baulieu EE. Chambraud B, et al. Among authors: baulieu ee. Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2658-63. doi: 10.1073/pnas.0914957107. Epub 2010 Jan 25. Proc Natl Acad Sci U S A. 2010. PMID: 20133804 Free PMC article.
A β-Turn Motif in the Steroid Hormone Receptor's Ligand-Binding Domains Interacts with the Peptidyl-prolyl Isomerase (PPIase) Catalytic Site of the Immunophilin FKBP52.
Byrne C, Henen MA, Belnou M, Cantrelle FX, Kamah A, Qi H, Giustiniani J, Chambraud B, Baulieu EE, Lippens G, Landrieu I, Jacquot Y. Byrne C, et al. Among authors: baulieu ee. Biochemistry. 2016 Sep 27;55(38):5366-76. doi: 10.1021/acs.biochem.6b00506. Epub 2016 Sep 19. Biochemistry. 2016. PMID: 27641460
Bioinspired Hybrid Fluorescent Ligands for the FK1 Domain of FKBP52.
de la Sierra-Gallay IL, Belnou M, Chambraud B, Genet M, van Tilbeurgh H, Aumont-Nicaise M, Desmadril M, Baulieu EE, Jacquot Y, Byrne C. de la Sierra-Gallay IL, et al. Among authors: baulieu ee. J Med Chem. 2020 Sep 24;63(18):10330-10338. doi: 10.1021/acs.jmedchem.0c00825. Epub 2020 Sep 15. J Med Chem. 2020. PMID: 32866001
751 results