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Application of in-vitro-cultured primary hepatocytes to evaluate species translatability and AAV transduction mechanisms of action.
Liu S, Razon L, Ritchie O, Sihn CR, Handyside B, Berguig G, Woloszynek J, Zhang L, Batty P, Lillicrap D, Agrawal V, Cortesio C, Gebretsadik K, Akeefe H, Colosi P, Kim B, Bunting S, Fong S. Liu S, et al. Among authors: batty p. Mol Ther Methods Clin Dev. 2022 May 29;26:61-71. doi: 10.1016/j.omtm.2022.05.008. eCollection 2022 Sep 8. Mol Ther Methods Clin Dev. 2022. PMID: 35782594 Free PMC article.
Lipid nanoparticles and siRNA targeting plasminogen provide lasting inhibition of fibrinolysis in mouse and dog models of hemophilia A.
Strilchuk AW, Hur WS, Batty P, Sang Y, Abrahams SR, Yong ASM, Leung J, Silva LM, Schroeder JA, Nesbitt K, de Laat B, Moutsopoulos NM, Bugge TH, Shi Q, Cullis PR, Merricks EP, Wolberg AS, Flick MJ, Lillicrap D, Nichols TC, Kastrup CJ. Strilchuk AW, et al. Among authors: batty p. Sci Transl Med. 2024 Feb 21;16(735):eadh0027. doi: 10.1126/scitranslmed.adh0027. Epub 2024 Feb 21. Sci Transl Med. 2024. PMID: 38381848
40 results