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Single-cell analyses reveal YAP/TAZ as regulators of stemness and cell plasticity in Glioblastoma.
Castellan M, Guarnieri A, Fujimura A, Zanconato F, Battilana G, Panciera T, Sladitschek HL, Contessotto P, Citron A, Grilli A, Romano O, Bicciato S, Fassan M, Porcù E, Rosato A, Cordenonsi M, Piccolo S. Castellan M, et al. Among authors: battilana g. Nat Cancer. 2021 Feb;2(2):174-188. doi: 10.1038/s43018-020-00150-z. Epub 2020 Dec 7. Nat Cancer. 2021. PMID: 33644767 Free PMC article.
YAP/TAZ as therapeutic targets in cancer.
Zanconato F, Battilana G, Cordenonsi M, Piccolo S. Zanconato F, et al. Among authors: battilana g. Curr Opin Pharmacol. 2016 Aug;29:26-33. doi: 10.1016/j.coph.2016.05.002. Epub 2016 Jun 2. Curr Opin Pharmacol. 2016. PMID: 27262779 Free PMC article. Review.
Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4.
Zanconato F, Battilana G, Forcato M, Filippi L, Azzolin L, Manfrin A, Quaranta E, Di Biagio D, Sigismondo G, Guzzardo V, Lejeune P, Haendler B, Krijgsveld J, Fassan M, Bicciato S, Cordenonsi M, Piccolo S. Zanconato F, et al. Among authors: battilana g. Nat Med. 2018 Oct;24(10):1599-1610. doi: 10.1038/s41591-018-0158-8. Epub 2018 Sep 17. Nat Med. 2018. PMID: 30224758 Free PMC article.
The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ.
Chang L, Azzolin L, Di Biagio D, Zanconato F, Battilana G, Lucon Xiccato R, Aragona M, Giulitti S, Panciera T, Gandin A, Sigismondo G, Krijgsveld J, Fassan M, Brusatin G, Cordenonsi M, Piccolo S. Chang L, et al. Among authors: battilana g. Nature. 2018 Nov;563(7730):265-269. doi: 10.1038/s41586-018-0658-1. Epub 2018 Oct 31. Nature. 2018. PMID: 30401838 Free PMC article.
Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties.
Panciera T, Citron A, Di Biagio D, Battilana G, Gandin A, Giulitti S, Forcato M, Bicciato S, Panzetta V, Fusco S, Azzolin L, Totaro A, Dei Tos AP, Fassan M, Vindigni V, Bassetto F, Rosato A, Brusatin G, Cordenonsi M, Piccolo S. Panciera T, et al. Among authors: battilana g. Nat Mater. 2020 Jul;19(7):797-806. doi: 10.1038/s41563-020-0615-x. Epub 2020 Feb 17. Nat Mater. 2020. PMID: 32066931 Free PMC article.
Mechanisms of YAP/TAZ transcriptional control.
Battilana G, Zanconato F, Piccolo S. Battilana G, et al. Cell Stress. 2021 Oct 29;5(11):167-172. doi: 10.15698/cst2021.11.258. eCollection 2021 Nov. Cell Stress. 2021. PMID: 34782888 Free PMC article. Review.
YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS-STING.
Sladitschek-Martens HL, Guarnieri A, Brumana G, Zanconato F, Battilana G, Xiccato RL, Panciera T, Forcato M, Bicciato S, Guzzardo V, Fassan M, Ulliana L, Gandin A, Tripodo C, Foiani M, Brusatin G, Cordenonsi M, Piccolo S. Sladitschek-Martens HL, et al. Among authors: battilana g. Nature. 2022 Jul;607(7920):790-798. doi: 10.1038/s41586-022-04924-6. Epub 2022 Jun 29. Nature. 2022. PMID: 35768505 Free PMC article.
Cell phenotypic plasticity requires autophagic flux driven by YAP/TAZ mechanotransduction.
Totaro A, Zhuang Q, Panciera T, Battilana G, Azzolin L, Brumana G, Gandin A, Brusatin G, Cordenonsi M, Piccolo S. Totaro A, et al. Among authors: battilana g. Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):17848-17857. doi: 10.1073/pnas.1908228116. Epub 2019 Aug 15. Proc Natl Acad Sci U S A. 2019. PMID: 31416916 Free PMC article.
45 results