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Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7.
Ismail HM, Barton V, Phanchana M, Charoensutthivarakul S, Wong MH, Hemingway J, Biagini GA, O'Neill PM, Ward SA. Ismail HM, et al. Among authors: barton v. Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2080-5. doi: 10.1073/pnas.1600459113. Epub 2016 Feb 8. Proc Natl Acad Sci U S A. 2016. PMID: 26858419 Free PMC article.
Inhibiting Plasmodium cytochrome bc1: a complex issue.
Barton V, Fisher N, Biagini GA, Ward SA, O'Neill PM. Barton V, et al. Curr Opin Chem Biol. 2010 Aug;14(4):440-6. doi: 10.1016/j.cbpa.2010.05.005. Curr Opin Chem Biol. 2010. PMID: 20570550 Review.
Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity.
Gibbons P, Verissimo E, Araujo NC, Barton V, Nixon GL, Amewu RK, Chadwick J, Stocks PA, Biagini GA, Srivastava A, Rosenthal PJ, Gut J, Guedes RC, Moreira R, Sharma R, Berry N, Cristiano ML, Shone AE, Ward SA, O'Neill PM. Gibbons P, et al. Among authors: barton v. J Med Chem. 2010 Nov 25;53(22):8202-6. doi: 10.1021/jm1009567. Epub 2010 Oct 27. J Med Chem. 2010. PMID: 20979352
Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins.
O'Neill PM, Amewu RK, Nixon GL, Bousejra ElGarah F, Mungthin M, Chadwick J, Shone AE, Vivas L, Lander H, Barton V, Muangnoicharoen S, Bray PG, Davies J, Park BK, Wittlin S, Brun R, Preschel M, Zhang K, Ward SA. O'Neill PM, et al. Among authors: barton v. Angew Chem Int Ed Engl. 2010 Aug 2;49(33):5693-7. doi: 10.1002/anie.201001026. Angew Chem Int Ed Engl. 2010. PMID: 20629058 No abstract available.
Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs.
Stocks PA, Bray PG, Barton VE, Al-Helal M, Jones M, Araujo NC, Gibbons P, Ward SA, Hughes RH, Biagini GA, Davies J, Amewu R, Mercer AE, Ellis G, O'Neill PM. Stocks PA, et al. Angew Chem Int Ed Engl. 2007;46(33):6278-83. doi: 10.1002/anie.200604697. Angew Chem Int Ed Engl. 2007. PMID: 17640025 No abstract available.
57 results