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Switching the three-component Biginelli-like reaction conditions for the regioselective synthesis of new 2-amino[1,2,4]triazolo[1,5-a]pyrimidines.
Pacetti M, Pismataro MC, Felicetti T, Giammarino F, Bonomini A, Tiecco M, Bertagnin C, Barreca ML, Germani R, Cecchetti V, Vicenti I, Tabarrini O, Zazzi M, Loregian A, Massari S. Pacetti M, et al. Among authors: barreca ml. Org Biomol Chem. 2024 Jan 24;22(4):767-783. doi: 10.1039/d3ob01861j. Org Biomol Chem. 2024. PMID: 38167738
1,2,4-Triazolo[1,5-a]pyrimidines: Efficient one-step synthesis and functionalization as influenza polymerase PA-PB1 interaction disruptors.
Pismataro MC, Felicetti T, Bertagnin C, Nizi MG, Bonomini A, Barreca ML, Cecchetti V, Jochmans D, De Jonghe S, Neyts J, Loregian A, Tabarrini O, Massari S. Pismataro MC, et al. Among authors: barreca ml. Eur J Med Chem. 2021 Oct 5;221:113494. doi: 10.1016/j.ejmech.2021.113494. Epub 2021 Apr 26. Eur J Med Chem. 2021. PMID: 33962311
Exploring the cycloheptathiophene-3-carboxamide scaffold to disrupt the interactions of the influenza polymerase subunits and obtain potent anti-influenza activity.
Desantis J, Nannetti G, Massari S, Barreca ML, Manfroni G, Cecchetti V, Palù G, Goracci L, Loregian A, Tabarrini O. Desantis J, et al. Among authors: barreca ml. Eur J Med Chem. 2017 Sep 29;138:128-139. doi: 10.1016/j.ejmech.2017.06.015. Epub 2017 Jun 8. Eur J Med Chem. 2017. PMID: 28666191
Sustainable, three-component, one-pot procedure to obtain active anti-flavivirus agents.
Felicetti T, Burali MS, Gwee CP, Ki Chan KW, Alonso S, Massari S, Sabatini S, Tabarrini O, Barreca ML, Cecchetti V, Vasudevan SG, Manfroni G. Felicetti T, et al. Among authors: barreca ml. Eur J Med Chem. 2021 Jan 15;210:112992. doi: 10.1016/j.ejmech.2020.112992. Epub 2020 Nov 4. Eur J Med Chem. 2021. PMID: 33208235
Corrigendum to "Exploring the cycloheptathiophene-3-carboxamide scaffold to disrupt the interactions of the influenza polymerase subunits and obtain potent anti-influenza activity" [Eur. J. Med. Chem. 138 (2017) 128-139].
Desantis J, Nannetti G, Massari S, Barreca ML, Manfroni G, Cecchetti V, Palù G, Goracci L, Loregian A, Tabarrini O. Desantis J, et al. Among authors: barreca ml. Eur J Med Chem. 2018 Aug 5;156:302-303. doi: 10.1016/j.ejmech.2018.07.009. Epub 2018 Jul 11. Eur J Med Chem. 2018. PMID: 30007243 No abstract available.
2-Phenylquinoline S. aureus NorA Efflux Pump Inhibitors: Evaluation of the Importance of Methoxy Group Introduction.
Felicetti T, Cannalire R, Pietrella D, Latacz G, Lubelska A, Manfroni G, Barreca ML, Massari S, Tabarrini O, Kieć-Kononowicz K, Schindler BD, Kaatz GW, Cecchetti V, Sabatini S. Felicetti T, et al. Among authors: barreca ml. J Med Chem. 2018 Sep 13;61(17):7827-7848. doi: 10.1021/acs.jmedchem.8b00791. Epub 2018 Aug 17. J Med Chem. 2018. PMID: 30067360
From Serendipity to Rational Identification of the 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one Core as a New Chemotype of AKT1 Inhibitors for Acute Myeloid Leukemia.
Astolfi A, Milano F, Palazzotti D, Brea J, Pismataro MC, Morlando M, Tabarrini O, Loza MI, Massari S, Martelli MP, Barreca ML. Astolfi A, et al. Among authors: barreca ml. Pharmaceutics. 2022 Oct 26;14(11):2295. doi: 10.3390/pharmaceutics14112295. Pharmaceutics. 2022. PMID: 36365115 Free PMC article.
102 results