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Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis.
Schepers M, Paes D, Tiane A, Rombaut B, Piccart E, van Veggel L, Gervois P, Wolfs E, Lambrichts I, Brullo C, Bruno O, Fedele E, Ricciarelli R, Ffrench-Constant C, Bechler ME, van Schaik P, Baron W, Lefevere E, Wasner K, Grünewald A, Verfaillie C, Baeten P, Broux B, Wieringa P, Hellings N, Prickaerts J, Vanmierlo T. Schepers M, et al. Among authors: baron w. Brain Behav Immun. 2023 Mar;109:1-22. doi: 10.1016/j.bbi.2022.12.020. Epub 2022 Dec 28. Brain Behav Immun. 2023. PMID: 36584795 Free article.
Fibronectin aggregation in multiple sclerosis lesions impairs remyelination.
Stoffels JM, de Jonge JC, Stancic M, Nomden A, van Strien ME, Ma D, Sisková Z, Maier O, Ffrench-Constant C, Franklin RJ, Hoekstra D, Zhao C, Baron W. Stoffels JM, et al. Among authors: baron w. Brain. 2013 Jan;136(Pt 1):116-31. doi: 10.1093/brain/aws313. Brain. 2013. PMID: 23365094
Oncostatin M-induced astrocytic tissue inhibitor of metalloproteinases-1 drives remyelination.
Houben E, Janssens K, Hermans D, Vandooren J, Van den Haute C, Schepers M, Vanmierlo T, Lambrichts I, van Horssen J, Baekelandt V, Opdenakker G, Baron W, Broux B, Slaets H, Hellings N. Houben E, et al. Among authors: baron w. Proc Natl Acad Sci U S A. 2020 Mar 3;117(9):5028-5038. doi: 10.1073/pnas.1912910117. Epub 2020 Feb 18. Proc Natl Acad Sci U S A. 2020. PMID: 32071226 Free PMC article.
114 results