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Saracatinib, a Selective Src Kinase Inhibitor, Blocks Fibrotic Responses in Preclinical Models of Pulmonary Fibrosis.
Ahangari F, Becker C, Foster DG, Chioccioli M, Nelson M, Beke K, Wang X, Justet A, Adams T, Readhead B, Meador C, Correll K, Lili LN, Roybal HM, Rose KA, Ding S, Barnthaler T, Briones N, DeIuliis G, Schupp JC, Li Q, Omote N, Aschner Y, Sharma L, Kopf KW, Magnusson B, Hicks R, Backmark A, Dela Cruz CS, Rosas I, Cousens LP, Dudley JT, Kaminski N, Downey GP. Ahangari F, et al. Among authors: barnthaler t. Am J Respir Crit Care Med. 2022 Dec 15;206(12):1463-1479. doi: 10.1164/rccm.202010-3832OC. Am J Respir Crit Care Med. 2022. PMID: 35998281 Free PMC article.
Mechanisms of Hypoxia-Induced Pulmonary Arterial Stiffening in Mice Revealed by a Functional Genetics Assay of Structural, Functional, and Transcriptomic Data.
Manning EP, Ramachandra AB, Schupp JC, Cavinato C, Raredon MSB, Bärnthaler T, Cosme C Jr, Singh I, Tellides G, Kaminski N, Humphrey JD. Manning EP, et al. Among authors: barnthaler t. Front Physiol. 2021 Sep 14;12:726253. doi: 10.3389/fphys.2021.726253. eCollection 2021. Front Physiol. 2021. PMID: 34594238 Free PMC article.
Characterization of the COPD alveolar niche using single-cell RNA sequencing.
Sauler M, McDonough JE, Adams TS, Kothapalli N, Barnthaler T, Werder RB, Schupp JC, Nouws J, Robertson MJ, Coarfa C, Yang T, Chioccioli M, Omote N, Cosme C Jr, Poli S, Ayaub EA, Chu SG, Jensen KH, Gomez JL, Britto CJ, Raredon MSB, Niklason LE, Wilson AA, Timshel PN, Kaminski N, Rosas IO. Sauler M, et al. Among authors: barnthaler t. Nat Commun. 2022 Jan 25;13(1):494. doi: 10.1038/s41467-022-28062-9. Nat Commun. 2022. PMID: 35078977 Free PMC article.
Dysregulation of metabolic pathways in pulmonary fibrosis.
Rajesh R, Atallah R, Bärnthaler T. Rajesh R, et al. Among authors: barnthaler t. Pharmacol Ther. 2023 Jun;246:108436. doi: 10.1016/j.pharmthera.2023.108436. Epub 2023 May 5. Pharmacol Ther. 2023. PMID: 37150402 Free article. Review.
Inhibiting eicosanoid degradation exerts antifibrotic effects in a pulmonary fibrosis mouse model and human tissue.
Bärnthaler T, Theiler A, Zabini D, Trautmann S, Stacher-Priehse E, Lanz I, Klepetko W, Sinn K, Flick H, Scheidl S, Thomas D, Olschewski H, Kwapiszewska G, Schuligoi R, Heinemann A. Bärnthaler T, et al. J Allergy Clin Immunol. 2020 Mar;145(3):818-833.e11. doi: 10.1016/j.jaci.2019.11.032. Epub 2019 Dec 5. J Allergy Clin Immunol. 2020. PMID: 31812575 Free article.
Activation of EP4 receptors prevents endotoxin-induced neutrophil infiltration into the airways and enhances microvascular barrier function.
Konya V, Maric J, Jandl K, Luschnig P, Aringer I, Lanz I, Platzer W, Theiler A, Bärnthaler T, Frei R, Marsche G, Marsh LM, Olschewski A, Lippe IT, Heinemann A, Schuligoi R. Konya V, et al. Among authors: barnthaler t. Br J Pharmacol. 2015 Sep;172(18):4454-4468. doi: 10.1111/bph.13229. Epub 2015 Jul 31. Br J Pharmacol. 2015. PMID: 26103450 Free PMC article.
The Role of PGE2 in Alveolar Epithelial and Lung Microvascular Endothelial Crosstalk.
Bärnthaler T, Maric J, Platzer W, Konya V, Theiler A, Hasenöhrl C, Gottschalk B, Trautmann S, Schreiber Y, Graier WF, Schicho R, Marsche G, Olschewski A, Thomas D, Schuligoi R, Heinemann A. Bärnthaler T, et al. Sci Rep. 2017 Aug 11;7(1):7923. doi: 10.1038/s41598-017-08228-y. Sci Rep. 2017. PMID: 28801643 Free PMC article.
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