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Convergent Chemoenzymatic Strategy to Deliver a Diversity of Shigella flexneri Serotype-Specific O-Antigen Segments from a Unique Lightly Protected Tetrasaccharide Core.
Hu Z, Benkoulouche M, Barel LA, Le Heiget G, Ben Imeddourene A, Le Guen Y, Monties N, Guerreiro C, Remaud-Siméon M, Moulis C, André I, Mulard LA. Hu Z, et al. Among authors: barel la. J Org Chem. 2021 Feb 5;86(3):2058-2075. doi: 10.1021/acs.joc.0c00777. J Org Chem. 2021. PMID: 32700907
Redirecting substrate regioselectivity using engineered ΔN123-GBD-CD2 branching sucrases for the production of pentasaccharide repeating units of S. flexneri 3a, 4a and 4b haptens.
Benkoulouche M, Ben Imeddourene A, Barel LA, Le Heiget G, Pizzut S, Kulyk H, Bellvert F, Bozonnet S, Mulard LA, Remaud-Siméon M, Moulis C, André I. Benkoulouche M, et al. Among authors: barel la. Sci Rep. 2021 Jan 28;11(1):2474. doi: 10.1038/s41598-021-81719-1. Sci Rep. 2021. PMID: 33510212 Free PMC article.
Computer-aided engineering of a branching sucrase for the glucodiversification of a tetrasaccharide precursor of S. flexneri antigenic oligosaccharides.
Benkoulouche M, Ben Imeddourene A, Barel LA, Lefebvre D, Fanuel M, Rogniaux H, Ropartz D, Barbe S, Guieysse D, Mulard LA, Remaud-Siméon M, Moulis C, André I. Benkoulouche M, et al. Among authors: barel la. Sci Rep. 2021 Oct 13;11(1):20294. doi: 10.1038/s41598-021-99384-9. Sci Rep. 2021. PMID: 34645865 Free PMC article.