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Botryosphaeran, [(1 → 3)(1 → 6)-β-D-glucan], induces apoptosis-like death in promastigotes of Leishmania amazonensis, and exerts a leishmanicidal effect on infected macrophages by activating NF-kB and producing pro-inflammatory molecules.
Carloto ACM, Bortoleti BTDS, Rodrigues ACJ, Silva TF, Tomiotto-Pellissier F, Bidóia DL, Gonçalves MD, Assolini JP, Dekker RFH, Barbosa-Dekker AM, Costa IN, Conchon-Costa I, Miranda-Sapla MM, Pavanelli WR. Carloto ACM, et al. Among authors: barbosa dekker am. Chem Biol Interact. 2022 Jan 5;351:109713. doi: 10.1016/j.cbi.2021.109713. Epub 2021 Oct 23. Chem Biol Interact. 2022. PMID: 34699765
Oral administration of botryosphaeran [(1 → 3)(1 → 6)-β-d-glucan] reduces inflammation through modulation of leukocytes and has limited effect on inflammatory nociception.
Silva NA, Pereira BG, Santos JA, Guarnier FA, Barbosa-Dekker AM, Dekker RFH, Kassuya CAL, Bernardes SS. Silva NA, et al. Among authors: barbosa dekker am. Cell Biochem Funct. 2022 Aug;40(6):578-588. doi: 10.1002/cbf.3727. Epub 2022 Jul 5. Cell Biochem Funct. 2022. PMID: 35788958
Anticancer effects of carboxymethylated (1→3)(1→6)-β-D-glucan (botryosphaeran) on multicellular tumor spheroids of MCF-7 cells as a model of breast cancer.
Fujiike AY, Lee CYAL, Rodrigues FST, Oliveira LCB, Barbosa-Dekker AM, Dekker RFH, Cólus IMS, Serpeloni JM. Fujiike AY, et al. Among authors: barbosa dekker am. J Toxicol Environ Health A. 2022 Jul 3;85(13):521-537. doi: 10.1080/15287394.2022.2048153. Epub 2022 Mar 7. J Toxicol Environ Health A. 2022. PMID: 35255775
In vivo antimutagenic and antiatherogenic effects of the (1 → 3)(1 → 6)-β-d- glucan botryosphaeran.
Silva-Sena GG, Malini M, Delarmelina JM, Dutra JCV, Gervásio SV, Leal MAS, Costa Pereira TM, Barbosa-Dekker AM, Dekker RFH, de Paula F, Batitucci MDCP. Silva-Sena GG, et al. Mutat Res Genet Toxicol Environ Mutagen. 2018 Feb;826:6-14. doi: 10.1016/j.mrgentox.2017.12.008. Epub 2017 Dec 21. Mutat Res Genet Toxicol Environ Mutagen. 2018. PMID: 29412871 Free article.
Botryosphaeran, a (1 → 3)(1 → 6)-β-D-glucan, reduces tumor development and cachexia syndrome in obese male rats by increasing insulin sensitivity and FOXO3a activity.
Geraldelli D, Ribeiro MC, Medeiros TC, Comiran PK, Martins KO, Oliveira MF, Oliveira GA, Dekker RFH, Barbosa-Dekker AM, Alegranci P, Queiroz EAIF. Geraldelli D, et al. Int J Biol Macromol. 2020 Dec 15;165(Pt A):985-994. doi: 10.1016/j.ijbiomac.2020.09.168. Epub 2020 Sep 28. Int J Biol Macromol. 2020. PMID: 32991890
35 results