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Direct and selective pharmacological disruption of the YAP-TEAD interface by IAG933 inhibits Hippo-dependent and RAS-MAPK-altered cancers.
Nat Cancer. 2024 Apr 2. doi: 10.1038/s43018-024-00754-9. Online ahead of print.
Nat Cancer. 2024.
PMID: 38565920
Cancer lineage-specific regulation of YAP responsive elements revealed through large-scale functional epigenomic screens.
Barbosa IAM, Gopalakrishnan R, Mercan S, Mourikis TP, Martin T, Wengert S, Sheng C, Ji F, Lopes R, Knehr J, Altorfer M, Lindeman A, Russ C, Naumann U, Golji J, Sprouffske K, Barys L, Tordella L, Schübeler D, Schmelzle T, Galli GG.
Barbosa IAM, et al.
Nat Commun. 2023 Jul 3;14(1):3907. doi: 10.1038/s41467-023-39527-w.
Nat Commun. 2023.
PMID: 37400441
Free PMC article.
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EVI1 drives leukemogenesis through aberrant ERG activation.
Schmoellerl J, Barbosa IAM, Minnich M, Andersch F, Smeenk L, Havermans M, Eder T, Neumann T, Jude J, Fellner M, Ebert A, Steininger M, Delwel R, Grebien F, Zuber J.
Schmoellerl J, et al. Among authors: barbosa iam.
Blood. 2023 Feb 2;141(5):453-466. doi: 10.1182/blood.2022016592.
Blood. 2023.
PMID: 36095844
Free article.
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Core-binding factor leukemia hijacks the T-cell-prone PU.1 antisense promoter.
van der Kouwe E, Heller G, Czibere A, Pulikkan JA, Agreiter C, Castilla LH, Delwel R, Di Ruscio A, Ebralidze AK, Forte M, Grebien F, Heyes E, Kazianka L, Klinger J, Kornauth C, Le T, Lind K, Barbosa IAM, Pemovska T, Pichler A, Schmolke AS, Schweicker CM, Sill H, Sperr WR, Spittler A, Surapally S, Trinh BQ, Valent P, Vanura K, Welner RS, Zuber J, Tenen DG, Staber PB.
van der Kouwe E, et al. Among authors: barbosa iam.
Blood. 2021 Oct 14;138(15):1345-1358. doi: 10.1182/blood.2020008971.
Blood. 2021.
PMID: 34010414
Free PMC article.
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CDK6 is an essential direct target of NUP98 fusion proteins in acute myeloid leukemia.
Schmoellerl J, Barbosa IAM, Eder T, Brandstoetter T, Schmidt L, Maurer B, Troester S, Pham HTT, Sagarajit M, Ebner J, Manhart G, Aslan E, Terlecki-Zaniewicz S, Van der Veen C, Hoermann G, Duployez N, Petit A, Lapillonne H, Puissant A, Itzykson R, Moriggl R, Heuser M, Meisel R, Valent P, Sexl V, Zuber J, Grebien F.
Schmoellerl J, et al. Among authors: barbosa iam.
Blood. 2020 Jul 23;136(4):387-400. doi: 10.1182/blood.2019003267.
Blood. 2020.
PMID: 32344427
Free PMC article.
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The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function.
Fonseca-Pereira D, Arroz-Madeira S, Rodrigues-Campos M, Barbosa IA, Domingues RG, Bento T, Almeida AR, Ribeiro H, Potocnik AJ, Enomoto H, Veiga-Fernandes H.
Fonseca-Pereira D, et al.
Nature. 2014 Oct 2;514(7520):98-101. doi: 10.1038/nature13498. Epub 2014 Jul 27.
Nature. 2014.
PMID: 25079320
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An optimized microRNA backbone for effective single-copy RNAi.
Fellmann C, Hoffmann T, Sridhar V, Hopfgartner B, Muhar M, Roth M, Lai DY, Barbosa IA, Kwon JS, Guan Y, Sinha N, Zuber J.
Fellmann C, et al.
Cell Rep. 2013 Dec 26;5(6):1704-13. doi: 10.1016/j.celrep.2013.11.020. Epub 2013 Dec 12.
Cell Rep. 2013.
PMID: 24332856
Free article.
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Genetic alterations in lung cancer: assessing limitations in routine clinical use.
Macedo JE, Costa AM, Barbosa IA, Rebelo S, de Moura CS, da Costa LT, Hespanhol V.
Macedo JE, et al.
Rev Port Pneumol. 2007 Jan-Feb;13(1):9-34. doi: 10.1016/s2173-5115(07)70320-2.
Rev Port Pneumol. 2007.
PMID: 17315088
Free article.
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