Barbiroli A - Search Results

1

A novel hotspot of gelsolin instability triggers an alternative mechanism of amyloid aggregation.

Bollati M, Diomede L, Giorgino T, Natale C, Fagnani E, Boniardi I, Barbiroli A, Alemani R, Beeg M, Gobbi M, Fakin A, Mastrangelo E, Milani M, Presciuttini G, Gabellieri E, Cioni P, de Rosa M. Bollati M, et al. Among authors: barbiroli a. Comput Struct Biotechnol J. 2021 Nov 19;19:6355-6365. doi: 10.1016/j.csbj.2021.11.025. eCollection 2021. Comput Struct Biotechnol J. 2021. PMID: 34938411 Free PMC article.

2

Structures of the lamin A/C R335W and E347K mutants: implications for dilated cardiolaminopathies.

Bollati M, Barbiroli A, Favalli V, Arbustini E, Charron P, Bolognesi M. Bollati M, et al. Among authors: barbiroli a. Biochem Biophys Res Commun. 2012 Feb 10;418(2):217-21. doi: 10.1016/j.bbrc.2011.12.136. Epub 2012 Jan 10. Biochem Biophys Res Commun. 2012. PMID: 22266370 Free article.

3

Decoding the Structural Bases of D76N ß2-Microglobulin High Amyloidogenicity through Crystallography and Asn-Scan Mutagenesis.

de Rosa M, Barbiroli A, Giorgetti S, Mangione PP, Bolognesi M, Ricagno S. de Rosa M, et al. Among authors: barbiroli a. PLoS One. 2015 Dec 1;10(12):e0144061. doi: 10.1371/journal.pone.0144061. eCollection 2015. PLoS One. 2015. PMID: 26625273 Free PMC article.

4

Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability.

Camilloni C, Sala BM, Sormanni P, Porcari R, Corazza A, De Rosa M, Zanini S, Barbiroli A, Esposito G, Bolognesi M, Bellotti V, Vendruscolo M, Ricagno S. Camilloni C, et al. Among authors: barbiroli a. Sci Rep. 2016 May 6;6:25559. doi: 10.1038/srep25559. Sci Rep. 2016. PMID: 27150430 Free PMC article.

5

Molecular basis of a novel renal amyloidosis due to N184K gelsolin variant.

Bonì F, Milani M, Porcari R, Barbiroli A, Ricagno S, de Rosa M. Bonì F, et al. Among authors: barbiroli a. Sci Rep. 2016 Sep 16;6:33463. doi: 10.1038/srep33463. Sci Rep. 2016. PMID: 27633054 Free PMC article.

6

Gelsolin pathogenic Gly167Arg mutation promotes domain-swap dimerization of the protein.

Bonì F, Milani M, Barbiroli A, Diomede L, Mastrangelo E, de Rosa M. Bonì F, et al. Among authors: barbiroli a. Hum Mol Genet. 2018 Jan 1;27(1):53-65. doi: 10.1093/hmg/ddx383. Hum Mol Genet. 2018. PMID: 29069428 Free PMC article.

7

Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity.

Le Marchand T, de Rosa M, Salvi N, Sala BM, Andreas LB, Barbet-Massin E, Sormanni P, Barbiroli A, Porcari R, Sousa Mota C, de Sanctis D, Bolognesi M, Emsley L, Bellotti V, Blackledge M, Camilloni C, Pintacuda G, Ricagno S. Le Marchand T, et al. Among authors: barbiroli a. Nat Commun. 2018 Apr 25;9(1):1658. doi: 10.1038/s41467-018-04078-y. Nat Commun. 2018. PMID: 29695721 Free PMC article.

8

Nanobody interaction unveils structure, dynamics and proteotoxicity of the Finnish-type amyloidogenic gelsolin variant.

Giorgino T, Mattioni D, Hassan A, Milani M, Mastrangelo E, Barbiroli A, Verhelle A, Gettemans J, Barzago MM, Diomede L, de Rosa M. Giorgino T, et al. Among authors: barbiroli a. Biochim Biophys Acta Mol Basis Dis. 2019 Mar 1;1865(3):648-660. doi: 10.1016/j.bbadis.2019.01.010. Epub 2019 Jan 6. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 30625383 Free article.

9

Modulating the cardiotoxic behaviour of immunoglobulin light chain dimers through point mutations.

Maritan M, Ambrosetti A, Oberti L, Barbiroli A, Diomede L, Romeo M, Lavatelli F, Sormanni P, Palladini G, Bolognesi M, Merlini G, Ricagno S. Maritan M, et al. Among authors: barbiroli a. Amyloid. 2019;26(sup1):105-106. doi: 10.1080/13506129.2019.1583185. Amyloid. 2019. PMID: 31343361 Free article. No abstract available.

10

The structure of N184K amyloidogenic variant of gelsolin highlights the role of the H-bond network for protein stability and aggregation properties.

de Rosa M, Barbiroli A, Bonì F, Scalone E, Mattioni D, Vanoni MA, Patrone M, Bollati M, Mastrangelo E, Giorgino T, Milani M. de Rosa M, et al. Among authors: barbiroli a. Eur Biophys J. 2020 Jan;49(1):11-19. doi: 10.1007/s00249-019-01409-9. Epub 2019 Nov 13. Eur Biophys J. 2020. PMID: 31724080

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