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Adenylosuccinate lyase is oncogenic in colorectal cancer by causing mitochondrial dysfunction and independent activation of NRF2 and mTOR-MYC-axis.
Taha-Mehlitz S, Bianco G, Coto-Llerena M, Kancherla V, Bantug GR, Gallon J, Ercan C, Panebianco F, Eppenberger-Castori S, von Strauss M, Staubli S, Bolli M, Peterli R, Matter MS, Terracciano LM, von Flüe M, Ng CKY, Soysal SD, Kollmar O, Piscuoglio S. Taha-Mehlitz S, et al. Among authors: bantug gr. Theranostics. 2021 Feb 15;11(9):4011-4029. doi: 10.7150/thno.50051. eCollection 2021. Theranostics. 2021. PMID: 33754045 Free PMC article.
Interferon lambda 4 can directly activate human CD19+ B cells and CD8+ T cells.
Coto-Llerena M, Lepore M, Spagnuolo J, Di Blasi D, Calabrese D, Suslov A, Bantug G, Duong FH, Terracciano LM, De Libero G, Heim MH. Coto-Llerena M, et al. Life Sci Alliance. 2020 Nov 6;4(1):e201900612. doi: 10.26508/lsa.201900612. Print 2021 Jan. Life Sci Alliance. 2020. PMID: 33158978 Free PMC article.
SDHA gain-of-function engages inflammatory mitochondrial retrograde signaling via KEAP1-Nrf2.
Burgener AV, Bantug GR, Meyer BJ, Higgins R, Ghosh A, Bignucolo O, Ma EH, Loeliger J, Unterstab G, Geigges M, Steiner R, Enamorado M, Ivanek R, Hunziker D, Schmidt A, Müller-Durovic B, Grählert J, Epple R, Dimeloe S, Lötscher J, Sauder U, Ebnöther M, Burger B, Heijnen I, Martínez-Cano S, Cantoni N, Brücker R, Kahlert CR, Sancho D, Jones RG, Navarini A, Recher M, Hess C. Burgener AV, et al. Among authors: bantug gr. Nat Immunol. 2019 Oct;20(10):1311-1321. doi: 10.1038/s41590-019-0482-2. Epub 2019 Sep 16. Nat Immunol. 2019. PMID: 31527833
Early effector maturation of naïve human CD8+ T cells requires mitochondrial biogenesis.
Fischer M, Bantug GR, Dimeloe S, Gubser PM, Burgener AV, Grählert J, Balmer ML, Develioglu L, Steiner R, Unterstab G, Sauder U, Hoenger G, Hess C. Fischer M, et al. Among authors: bantug gr. Eur J Immunol. 2018 Oct;48(10):1632-1643. doi: 10.1002/eji.201747443. Epub 2018 Aug 7. Eur J Immunol. 2018. PMID: 30028501 Free article.
The immunometabolic ecosystem in cancer.
Bantug GR, Hess C. Bantug GR, et al. Nat Immunol. 2023 Dec;24(12):2008-2020. doi: 10.1038/s41590-023-01675-y. Epub 2023 Nov 27. Nat Immunol. 2023. PMID: 38012409 Review.
28 results