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Dual blockade of IL-4 and IL-13 with dupilumab, an IL-4Rα antibody, is required to broadly inhibit type 2 inflammation.
Le Floc'h A, Allinne J, Nagashima K, Scott G, Birchard D, Asrat S, Bai Y, Lim WK, Martin J, Huang T, Potocky TB, Kim JH, Rafique A, Papadopoulos NJ, Stahl N, Yancopoulos GD, Murphy AJ, Sleeman MA, Orengo JM. Le Floc'h A, et al. Among authors: bai y. Allergy. 2020 May;75(5):1188-1204. doi: 10.1111/all.14151. Epub 2020 Jan 3. Allergy. 2020. PMID: 31838750 Free PMC article.
C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production, and glomerulonephropathy in mice.
Atanasio A, Decman V, White D, Ramos M, Ikiz B, Lee HC, Siao CJ, Brydges S, LaRosa E, Bai Y, Fury W, Burfeind P, Zamfirova R, Warshaw G, Orengo J, Oyejide A, Fralish M, Auerbach W, Poueymirou W, Freudenberg J, Gong G, Zambrowicz B, Valenzuela D, Yancopoulos G, Murphy A, Thurston G, Lai KM. Atanasio A, et al. Among authors: bai y. Sci Rep. 2016 Mar 16;6:23204. doi: 10.1038/srep23204. Sci Rep. 2016. PMID: 26979938 Free PMC article.
Activin A more prominently regulates muscle mass in primates than does GDF8.
Latres E, Mastaitis J, Fury W, Miloscio L, Trejos J, Pangilinan J, Okamoto H, Cavino K, Na E, Papatheodorou A, Willer T, Bai Y, Hae Kim J, Rafique A, Jaspers S, Stitt T, Murphy AJ, Yancopoulos GD, Gromada J. Latres E, et al. Among authors: bai y. Nat Commun. 2017 Apr 28;8:15153. doi: 10.1038/ncomms15153. Nat Commun. 2017. PMID: 28452368 Free PMC article.
Molecular taxonomy of human ocular outflow tissues defined by single-cell transcriptomics.
Patel G, Fury W, Yang H, Gomez-Caraballo M, Bai Y, Yang T, Adler C, Wei Y, Ni M, Schmitt H, Hu Y, Yancopoulos G, Stamer WD, Romano C. Patel G, et al. Among authors: bai y. Proc Natl Acad Sci U S A. 2020 Jun 9;117(23):12856-12867. doi: 10.1073/pnas.2001896117. Epub 2020 May 21. Proc Natl Acad Sci U S A. 2020. PMID: 32439707 Free PMC article.
Humanized C3 Mouse: A Novel Accelerated Model of C3 Glomerulopathy.
Devalaraja-Narashimha K, Meagher K, Luo Y, Huang C, Kaplan T, Muthuswamy A, Halasz G, Casanova S, O'Brien J, Peyser Boiarsky R, McWhirter J, Gartner H, Bai Y, MacDonnell S, Liu C, Hu Y, Latuszek A, Wei Y, Prasad S, Huang T, Yancopoulos G, Murphy A, Olson W, Zambrowicz B, Macdonald L, Morton LG. Devalaraja-Narashimha K, et al. Among authors: bai y. J Am Soc Nephrol. 2021 Jan;32(1):99-114. doi: 10.1681/ASN.2020050698. Epub 2020 Dec 7. J Am Soc Nephrol. 2021. PMID: 33288630 Free PMC article.
Enhanced IL-36R signaling promotes barrier impairment and inflammation in skin and intestine.
Hovhannisyan Z, Liu N, Khalil-Aguero S, Panea C, VanValkenburgh J, Zhang R, Lim WK, Bai Y, Fury W, Huang T, Garnova E, Fairhurst J, Kim J, Aryal S, Ajithdoss D, Oyejide A, Del Pilar Molina-Portela M, E H, Poueymirou W, Oristian NS, Brydges S, Liu X, Olson W, Yancopoulos G, Murphy AJ, Sleeman MA, Haxhinasto S. Hovhannisyan Z, et al. Among authors: bai y. Sci Immunol. 2020 Dec 18;5(54):eaax1686. doi: 10.1126/sciimmunol.aax1686. Sci Immunol. 2020. PMID: 33443029
Role of Interleukin-1 Signaling in a Mouse Model of Kawasaki Disease-Associated Abdominal Aortic Aneurysm.
Wakita D, Kurashima Y, Crother TR, Noval Rivas M, Lee Y, Chen S, Fury W, Bai Y, Wagner S, Li D, Lehman T, Fishbein MC, Hoffman HM, Shah PK, Shimada K, Arditi M. Wakita D, et al. Among authors: bai y. Arterioscler Thromb Vasc Biol. 2016 May;36(5):886-97. doi: 10.1161/ATVBAHA.115.307072. Epub 2016 Mar 3. Arterioscler Thromb Vasc Biol. 2016. PMID: 26941015 Free PMC article.
Pharmacological inhibition of NPY receptors illustrates dissociable features of experimental colitis in the mouse DSS model: Implications for preclinical evaluation of efficacy in an inflammatory bowel disease model.
Ruiz HH, Becker S, Bai Y, Cortes-Burgos LA, Eckersdorff MM, Macdonald LE, Croll SD. Ruiz HH, et al. Among authors: bai y. PLoS One. 2019 Aug 1;14(8):e0220156. doi: 10.1371/journal.pone.0220156. eCollection 2019. PLoS One. 2019. PMID: 31369588 Free PMC article.
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