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A next-generation BRAF inhibitor overcomes resistance to BRAF inhibition in patients with BRAF-mutant cancers using pharmacokinetics-informed dose escalation.
Yaeger R, McKean MA, Haq R, Beck JT, Taylor MH, Cohen JE, Bowles DW, Gadgeel SM, Mihalcioiu C, Papadopoulos KP, Diamond EL, Sturtz KB, Feng G, Drescher SK, Reddy MB, Sengupta B, Maity AK, Brown SA, Singh A, Brown EN, Baer BR, Wong J, Mou TC, Wu WI, Kahn DR, Gadal S, Rosen N, Gaudino JJ, Lee PA, Hartley DP, Rothenberg SM. Yaeger R, et al. Among authors: baer br. Cancer Discov. 2024 Apr 30. doi: 10.1158/2159-8290.CD-24-0024. Online ahead of print. Cancer Discov. 2024. PMID: 38691346
Three comments on the RIR method.
Baer BR, Charlson M, Fremes SE, Gaudino M, Wells MT. Baer BR, et al. J Clin Epidemiol. 2022 Jun;146:123-124. doi: 10.1016/j.jclinepi.2022.01.021. Epub 2022 Feb 3. J Clin Epidemiol. 2022. PMID: 35122978 No abstract available.
Fragility indices for only sufficiently likely modifications.
Baer BR, Gaudino M, Charlson M, Fremes SE, Wells MT. Baer BR, et al. Proc Natl Acad Sci U S A. 2021 Dec 7;118(49):e2105254118. doi: 10.1073/pnas.2105254118. Proc Natl Acad Sci U S A. 2021. PMID: 34848537 Free PMC article.
30 results