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TDP-43 proteinopathy in ALS is triggered by loss of ASRGL1 and associated with HML-2 expression.
Garcia-Montojo M, Fathi S, Rastegar C, Simula ER, Doucet-O'Hare T, Cheng YHH, Abrams RPM, Pasternack N, Malik N, Bachani M, Disanza B, Maric D, Lee MH, Wang H, Santamaria U, Li W, Sampson K, Lorenzo JR, Sanchez IE, Mezghrani A, Li Y, Sechi LA, Pineda S, Heiman M, Kellis M, Steiner J, Nath A. Garcia-Montojo M, et al. Among authors: bachani m. Nat Commun. 2024 May 16;15(1):4163. doi: 10.1038/s41467-024-48488-7. Nat Commun. 2024. PMID: 38755145 Free PMC article.
Neurotoxic properties of the Zika virus envelope protein.
Steiner JP, Bachani M, Malik N, Li W, Tyagi R, Sampson K, Abrams RPM, Kousa Y, Solis J, Johnson TP, Nath A. Steiner JP, et al. Among authors: bachani m. Exp Neurol. 2023 Sep;367:114469. doi: 10.1016/j.expneurol.2023.114469. Epub 2023 Jun 14. Exp Neurol. 2023. PMID: 37327963
Chronic neuronal activation leads to elevated lactate dehydrogenase A through the AMP-activated protein kinase/hypoxia-inducible factor-1α hypoxia pathway.
Ksendzovsky A, Bachani M, Altshuler M, Walbridge S, Mortazavi A, Moyer M, Chen C, Fayed I, Steiner J, Edwards N, Inati SK, Jahanipour J, Maric D, Heiss JD, Kapur J, Zaghloul KA. Ksendzovsky A, et al. Among authors: bachani m. Brain Commun. 2022 Dec 1;5(1):fcac298. doi: 10.1093/braincomms/fcac298. eCollection 2023. Brain Commun. 2022. PMID: 36655171 Free PMC article.
Fluconazole Is Neuroprotective via Interactions with the IGF-1 Receptor.
Toodle V, Lee MH, Bachani M, Ruffin A, Vivekanandhan S, Malik N, Wang T, Johnson TP, Nath A, Steiner JP. Toodle V, et al. Among authors: bachani m. Neurotherapeutics. 2022 Jul;19(4):1313-1328. doi: 10.1007/s13311-022-01265-0. Epub 2022 Jul 13. Neurotherapeutics. 2022. PMID: 35831747 Free PMC article.
Human Endogenous Retrovirus K Envelope in Spinal Fluid of Amyotrophic Lateral Sclerosis Is Toxic.
Steiner JP, Bachani M, Malik N, DeMarino C, Li W, Sampson K, Lee MH, Kowalak J, Bhaskar M, Doucet-O'Hare T, Garcia-Montojo M, Cowen M, Smith B, Reoma LB, Medina J, Brunel J, Pierquin J, Charvet B, Perron H, Nath A. Steiner JP, et al. Among authors: bachani m. Ann Neurol. 2022 Oct;92(4):545-561. doi: 10.1002/ana.26452. Epub 2022 Jul 30. Ann Neurol. 2022. PMID: 35801347 Free PMC article.
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Abrams RPM, Yasgar A, Teramoto T, Lee MH, Dorjsuren D, Eastman RT, Malik N, Zakharov AV, Li W, Bachani M, Brimacombe K, Steiner JP, Hall MD, Balasubramanian A, Jadhav A, Padmanabhan R, Simeonov A, Nath A. Abrams RPM, et al. Among authors: bachani m. Proc Natl Acad Sci U S A. 2020 Dec 8;117(49):31365-31375. doi: 10.1073/pnas.2005463117. Epub 2020 Nov 23. Proc Natl Acad Sci U S A. 2020. PMID: 33229545 Free PMC article.
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