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Exploration of the molecular architecture of the orthosteric binding site in the α4β2 nicotinic acetylcholine receptor with analogs of 3-(dimethylamino)butyl dimethylcarbamate (DMABC) and 1-(pyridin-3-yl)-1,4-diazepane.
Eur J Med Chem. 2015 Sep 18;102:425-44. doi: 10.1016/j.ejmech.2015.07.024. Epub 2015 Jul 17.
Eur J Med Chem. 2015.
PMID: 26301559
General synthesis of β-alanine-containing spider polyamine toxins and discovery of nephila polyamine toxins 1 and 8 as highly potent inhibitors of ionotropic glutamate receptors.
Lucas S, Poulsen MH, Nørager NG, Barslund AF, Bach TB, Kristensen AS, Strømgaard K.
Lucas S, et al. Among authors: bach tb.
J Med Chem. 2012 Nov 26;55(22):10297-301. doi: 10.1021/jm301255m. Epub 2012 Nov 6.
J Med Chem. 2012.
PMID: 23092360
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Structure-activity relationship studies of argiotoxins: selective and potent inhibitors of ionotropic glutamate receptors.
Poulsen MH, Lucas S, Bach TB, Barslund AF, Wenzler C, Jensen CB, Kristensen AS, Strømgaard K.
Poulsen MH, et al. Among authors: bach tb.
J Med Chem. 2013 Feb 14;56(3):1171-81. doi: 10.1021/jm301602d. Epub 2013 Jan 15.
J Med Chem. 2013.
PMID: 23320429
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Solid-phase synthesis and biological evaluation of Joro spider toxin-4 from Nephila clavata.
Barslund AF, Poulsen MH, Bach TB, Lucas S, Kristensen AS, Strømgaard K.
Barslund AF, et al. Among authors: bach tb.
J Nat Prod. 2011 Mar 25;74(3):483-6. doi: 10.1021/np100746w. Epub 2010 Dec 28.
J Nat Prod. 2011.
PMID: 21188966
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