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Age-dependent alveolar epithelial plasticity orchestrates lung homeostasis and regeneration.
Penkala IJ, Liberti DC, Pankin J, Sivakumar A, Kremp MM, Jayachandran S, Katzen J, Leach JP, Windmueller R, Stolz K, Morley MP, Babu A, Zhou S, Frank DB, Morrisey EE. Penkala IJ, et al. Among authors: babu a. Cell Stem Cell. 2021 Oct 7;28(10):1775-1789.e5. doi: 10.1016/j.stem.2021.04.026. Epub 2021 May 10. Cell Stem Cell. 2021. PMID: 33974915 Free PMC article.
Genome-Nuclear Lamina Interactions Regulate Cardiac Stem Cell Lineage Restriction.
Poleshko A, Shah PP, Gupta M, Babu A, Morley MP, Manderfield LJ, Ifkovits JL, Calderon D, Aghajanian H, Sierra-Pagán JE, Sun Z, Wang Q, Li L, Dubois NC, Morrisey EE, Lazar MA, Smith CL, Epstein JA, Jain R. Poleshko A, et al. Among authors: babu a. Cell. 2017 Oct 19;171(3):573-587.e14. doi: 10.1016/j.cell.2017.09.018. Epub 2017 Oct 12. Cell. 2017. PMID: 29033129 Free PMC article.
Early lineage specification defines alveolar epithelial ontogeny in the murine lung.
Frank DB, Penkala IJ, Zepp JA, Sivakumar A, Linares-Saldana R, Zacharias WJ, Stolz KG, Pankin J, Lu M, Wang Q, Babu A, Li L, Zhou S, Morley MP, Jain R, Morrisey EE. Frank DB, et al. Among authors: babu a. Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4362-4371. doi: 10.1073/pnas.1813952116. Epub 2019 Feb 19. Proc Natl Acad Sci U S A. 2019. PMID: 30782824 Free PMC article.
mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline.
Obraztsova K, Basil MC, Rue R, Sivakumar A, Lin SM, Mukhitov AR, Gritsiuta AI, Evans JF, Kopp M, Katzen J, Robichaud A, Atochina-Vasserman EN, Li S, Carl J, Babu A, Morley MP, Cantu E, Beers MF, Frank DB, Morrisey EE, Krymskaya VP. Obraztsova K, et al. Among authors: babu a. Nat Commun. 2020 Nov 6;11(1):5640. doi: 10.1038/s41467-020-18979-4. Nat Commun. 2020. PMID: 33159078 Free PMC article.
Genomic, epigenomic, and biophysical cues controlling the emergence of the lung alveolus.
Zepp JA, Morley MP, Loebel C, Kremp MM, Chaudhry FN, Basil MC, Leach JP, Liberti DC, Niethamer TK, Ying Y, Jayachandran S, Babu A, Zhou S, Frank DB, Burdick JA, Morrisey EE. Zepp JA, et al. Among authors: babu a. Science. 2021 Mar 12;371(6534):eabc3172. doi: 10.1126/science.abc3172. Science. 2021. PMID: 33707239 Free PMC article.
Human distal airways contain a multipotent secretory cell that can regenerate alveoli.
Basil MC, Cardenas-Diaz FL, Kathiriya JJ, Morley MP, Carl J, Brumwell AN, Katzen J, Slovik KJ, Babu A, Zhou S, Kremp MM, McCauley KB, Li S, Planer JD, Hussain SS, Liu X, Windmueller R, Ying Y, Stewart KM, Oyster M, Christie JD, Diamond JM, Engelhardt JF, Cantu E, Rowe SM, Kotton DN, Chapman HA, Morrisey EE. Basil MC, et al. Among authors: babu a. Nature. 2022 Apr;604(7904):120-126. doi: 10.1038/s41586-022-04552-0. Epub 2022 Mar 30. Nature. 2022. PMID: 35355013 Free PMC article.
685 results