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Emergence of methicillin resistance predates the clinical use of antibiotics.
Larsen J, Raisen CL, Ba X, Sadgrove NJ, Padilla-González GF, Simmonds MSJ, Loncaric I, Kerschner H, Apfalter P, Hartl R, Deplano A, Vandendriessche S, Černá Bolfíková B, Hulva P, Arendrup MC, Hare RK, Barnadas C, Stegger M, Sieber RN, Skov RL, Petersen A, Angen Ø, Rasmussen SL, Espinosa-Gongora C, Aarestrup FM, Lindholm LJ, Nykäsenoja SM, Laurent F, Becker K, Walther B, Kehrenberg C, Cuny C, Layer F, Werner G, Witte W, Stamm I, Moroni P, Jørgensen HJ, de Lencastre H, Cercenado E, García-Garrote F, Börjesson S, Hæggman S, Perreten V, Teale CJ, Waller AS, Pichon B, Curran MD, Ellington MJ, Welch JJ, Peacock SJ, Seilly DJ, Morgan FJE, Parkhill J, Hadjirin NF, Lindsay JA, Holden MTG, Edwards GF, Foster G, Paterson GK, Didelot X, Holmes MA, Harrison EM, Larsen AR. Larsen J, et al. Among authors: ba x. Nature. 2022 Feb;602(7895):135-141. doi: 10.1038/s41586-021-04265-w. Epub 2022 Jan 5. Nature. 2022. PMID: 34987223 Free PMC article.
Novel mutations in penicillin-binding protein genes in clinical Staphylococcus aureus isolates that are methicillin resistant on susceptibility testing, but lack the mec gene.
Ba X, Harrison EM, Edwards GF, Holden MT, Larsen AR, Petersen A, Skov RL, Peacock SJ, Parkhill J, Paterson GK, Holmes MA. Ba X, et al. J Antimicrob Chemother. 2014 Mar;69(3):594-7. doi: 10.1093/jac/dkt418. Epub 2013 Nov 11. J Antimicrob Chemother. 2014. PMID: 24216768 Free PMC article.
A novel hybrid SCCmec-mecC region in Staphylococcus sciuri.
Harrison EM, Paterson GK, Holden MT, Ba X, Rolo J, Morgan FJ, Pichon B, Kearns A, Zadoks RN, Peacock SJ, Parkhill J, Holmes MA. Harrison EM, et al. Among authors: ba x. J Antimicrob Chemother. 2014 Apr;69(4):911-8. doi: 10.1093/jac/dkt452. Epub 2013 Dec 2. J Antimicrob Chemother. 2014. PMID: 24302651 Free PMC article.
Old Drugs To Treat Resistant Bugs: Methicillin-Resistant Staphylococcus aureus Isolates with mecC Are Susceptible to a Combination of Penicillin and Clavulanic Acid.
Ba X, Harrison EM, Lovering AL, Gleadall N, Zadoks R, Parkhill J, Peacock SJ, Holden MT, Paterson GK, Holmes MA. Ba X, et al. Antimicrob Agents Chemother. 2015 Dec;59(12):7396-404. doi: 10.1128/AAC.01469-15. Epub 2015 Sep 21. Antimicrob Agents Chemother. 2015. PMID: 26392513 Free PMC article.
PBP2a substitutions linked to ceftaroline resistance in MRSA isolates from the UK.
Harrison EM, Ba X, Blane B, Ellington MJ, Loeffler A, Hill RL, Holmes MA, Peacock SJ. Harrison EM, et al. Among authors: ba x. J Antimicrob Chemother. 2016 Jan;71(1):268-9. doi: 10.1093/jac/dkv317. Epub 2015 Oct 12. J Antimicrob Chemother. 2016. PMID: 26462986 Free PMC article. No abstract available.
Identification of LukPQ, a novel, equid-adapted leukocidin of Staphylococcus aureus.
Koop G, Vrieling M, Storisteanu DM, Lok LS, Monie T, van Wigcheren G, Raisen C, Ba X, Gleadall N, Hadjirin N, Timmerman AJ, Wagenaar JA, Klunder HM, Fitzgerald JR, Zadoks R, Paterson GK, Torres C, Waller AS, Loeffler A, Loncaric I, Hoet AE, Bergström K, De Martino L, Pomba C, de Lencastre H, Ben Slama K, Gharsa H, Richardson EJ, Chilvers ER, de Haas C, van Kessel K, van Strijp JA, Harrison EM, Holmes MA. Koop G, et al. Among authors: ba x. Sci Rep. 2017 Jan 20;7:40660. doi: 10.1038/srep40660. Sci Rep. 2017. PMID: 28106142 Free PMC article.
Genomic identification of cryptic susceptibility to penicillins and β-lactamase inhibitors in methicillin-resistant Staphylococcus aureus.
Harrison EM, Ba X, Coll F, Blane B, Restif O, Carvell H, Köser CU, Jamrozy D, Reuter S, Lovering A, Gleadall N, Bellis KL, Uhlemann AC, Lowy FD, Massey RC, Grilo IR, Sobral R, Larsen J, Rhod Larsen A, Vingsbo Lundberg C, Parkhill J, Paterson GK, Holden MTG, Peacock SJ, Holmes MA. Harrison EM, et al. Among authors: ba x. Nat Microbiol. 2019 Oct;4(10):1680-1691. doi: 10.1038/s41564-019-0471-0. Epub 2019 Jun 24. Nat Microbiol. 2019. PMID: 31235959 Free PMC article.
292 results