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Exploration of Pyrazolo[1,5-a]pyrimidines as Membrane-Bound Pyrophosphatase Inhibitors.
Johansson NG, Dreano L, Vidilaseris K, Khattab A, Liu J, Lasbleiz A, Ribeiro O, Kiriazis A, Boije Af Gennäs G, Meri S, Goldman A, Yli-Kauhaluoma J, Xhaard H. Johansson NG, et al. ChemMedChem. 2021 Nov 5;16(21):3360-3367. doi: 10.1002/cmdc.202100392. Epub 2021 Oct 12. ChemMedChem. 2021. PMID: 34459148 Free PMC article.
IMPROvER: the Integral Membrane Protein Stability Selector.
Harborne SPD, Strauss J, Boakes JC, Wright DL, Henderson JG, Boivineau J, Jaakola VP, Goldman A. Harborne SPD, et al. Sci Rep. 2020 Sep 16;10(1):15165. doi: 10.1038/s41598-020-71744-x. Sci Rep. 2020. PMID: 32938971 Free PMC article.
Affimer proteins inhibit immune complex binding to FcγRIIIa with high specificity through competitive and allosteric modes of action.
Robinson JI, Baxter EW, Owen RL, Thomsen M, Tomlinson DC, Waterhouse MP, Win SJ, Nettleship JE, Tiede C, Foster RJ, Owens RJ, Fishwick CWG, Harris SA, Goldman A, McPherson MJ, Morgan AW. Robinson JI, et al. Proc Natl Acad Sci U S A. 2018 Jan 2;115(1):E72-E81. doi: 10.1073/pnas.1707856115. Epub 2017 Dec 15. Proc Natl Acad Sci U S A. 2018. PMID: 29247053 Free PMC article.