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Genetic and pharmacological inhibition of XBP1 protects against APAP hepatotoxicity through the activation of autophagy.
Ye H, Chen C, Wu H, Zheng K, Martín-Adrados B, Caparros E, Francés R, Nelson LJ, Gómez Del Moral M, Asensio I, Vaquero J, Bañares R, Ávila MA, Andrade RJ, Isabel Lucena M, Martínez-Chantar ML, Reeves HL, Masson S, Blumberg RS, Gracia-Sancho J, Nevzorova YA, Martínez-Naves E, Cubero FJ. Ye H, et al. Cell Death Dis. 2022 Feb 10;13(2):143. doi: 10.1038/s41419-022-04580-8. Cell Death Dis. 2022. PMID: 35145060 Free PMC article.
Advanced preclinical models for evaluation of drug-induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET].
Fernandez-Checa JC, Bagnaninchi P, Ye H, Sancho-Bru P, Falcon-Perez JM, Royo F, Garcia-Ruiz C, Konu O, Miranda J, Lunov O, Dejneka A, Elfick A, McDonald A, Sullivan GJ, Aithal GP, Lucena MI, Andrade RJ, Fromenty B, Kranendonk M, Cubero FJ, Nelson LJ. Fernandez-Checa JC, et al. J Hepatol. 2021 Oct;75(4):935-959. doi: 10.1016/j.jhep.2021.06.021. Epub 2021 Jun 24. J Hepatol. 2021. PMID: 34171436 Free article. Review.
Low-dose acetaminophen induces early disruption of cell-cell tight junctions in human hepatic cells and mouse liver.
Gamal W, Treskes P, Samuel K, Sullivan GJ, Siller R, Srsen V, Morgan K, Bryans A, Kozlowska A, Koulovasilopoulos A, Underwood I, Smith S, Del-Pozo J, Moss S, Thompson AI, Henderson NC, Hayes PC, Plevris JN, Bagnaninchi PO, Nelson LJ. Gamal W, et al. Sci Rep. 2017 Jan 30;7:37541. doi: 10.1038/srep37541. Sci Rep. 2017. PMID: 28134251 Free PMC article.