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Genetic and pharmacological inhibition of XBP1 protects against APAP hepatotoxicity through the activation of autophagy.
Cell Death Dis. 2022 Feb 10;13(2):143. doi: 10.1038/s41419-022-04580-8.
Cell Death Dis. 2022.
PMID: 35145060
Free PMC article.
Advanced preclinical models for evaluation of drug-induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET].
Fernandez-Checa JC, Bagnaninchi P, Ye H, Sancho-Bru P, Falcon-Perez JM, Royo F, Garcia-Ruiz C, Konu O, Miranda J, Lunov O, Dejneka A, Elfick A, McDonald A, Sullivan GJ, Aithal GP, Lucena MI, Andrade RJ, Fromenty B, Kranendonk M, Cubero FJ, Nelson LJ.
Fernandez-Checa JC, et al.
J Hepatol. 2021 Oct;75(4):935-959. doi: 10.1016/j.jhep.2021.06.021. Epub 2021 Jun 24.
J Hepatol. 2021.
PMID: 34171436
Free article.
Review.
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Validation of Reference Genes for Gene Expression Studies by RT-qPCR in HepaRG Cells during Toxicity Testing and Disease Modelling.
Brzeszczyńska J, Brzeszczyński F, Samuel K, Morgan K, Morley SD, Plevris JN, Hayes PC.
Brzeszczyńska J, et al.
Cells. 2020 Mar 21;9(3):770. doi: 10.3390/cells9030770.
Cells. 2020.
PMID: 32245194
Free PMC article.
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Low-dose acetaminophen induces early disruption of cell-cell tight junctions in human hepatic cells and mouse liver.
Gamal W, Treskes P, Samuel K, Sullivan GJ, Siller R, Srsen V, Morgan K, Bryans A, Kozlowska A, Koulovasilopoulos A, Underwood I, Smith S, Del-Pozo J, Moss S, Thompson AI, Henderson NC, Hayes PC, Plevris JN, Bagnaninchi PO, Nelson LJ.
Gamal W, et al.
Sci Rep. 2017 Jan 30;7:37541. doi: 10.1038/srep37541.
Sci Rep. 2017.
PMID: 28134251
Free PMC article.
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Acetaminophen cytotoxicity is ameliorated in a human liver organotypic co-culture model.
Nelson LJ, Navarro M, Treskes P, Samuel K, Tura-Ceide O, Morley SD, Hayes PC, Plevris JN.
Nelson LJ, et al.
Sci Rep. 2015 Dec 3;5:17455. doi: 10.1038/srep17455.
Sci Rep. 2015.
PMID: 26632255
Free PMC article.
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