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Synergistic lethality in chronic myeloid leukemia - targeting oxidative phosphorylation and unfolded protein response effectively complements tyrosine kinase inhibitor treatment.
Häselbarth L, Gamali S, Saul D, Krumbholz M, Böttcher-Loschinski R, Böttcher M, Zou D, Metzler M, Karow A, Mougiakakos D. Häselbarth L, et al. Among authors: bottcher loschinski r. BMC Cancer. 2023 Nov 27;23(1):1153. doi: 10.1186/s12885-023-11623-6. BMC Cancer. 2023. PMID: 38012567 Free PMC article.
Accumulation of T-cell-suppressive PD-L1high extracellular vesicles is associated with GvHD and might impact GvL efficacy.
Baur R, Karl F, Böttcher-Loschinski R, Stoll A, Völkl S, Gießl A, Flamann C, Bruns H, Schlötzer-Schrehardt U, Böttcher M, Schewe DM, Fischer T, Jitschin R, Mackensen A, Mougiakakos D. Baur R, et al. Among authors: bottcher loschinski r. J Immunother Cancer. 2023 Mar;11(3):e006362. doi: 10.1136/jitc-2022-006362. J Immunother Cancer. 2023. PMID: 36898735 Free PMC article.
Oxidative DNA damage in reconstituting T cells is associated with relapse and inferior survival after allo-SCT.
Karl F, Liang C, Böttcher-Loschinski R, Stoll A, Flamann C, Richter S, Lischer C, Völkl S, Jacobs B, Böttcher M, Jitschin R, Bruns H, Fischer T, Holler E, Rösler W, Dandekar T, Mackensen A, Mougiakakos D. Karl F, et al. Among authors: bottcher loschinski r. Blood. 2023 Mar 30;141(13):1626-1639. doi: 10.1182/blood.2022017267. Blood. 2023. PMID: 36564029 Free article.
Lipotoxicity as a Barrier for T Cell-Based Therapies.
Böttcher-Loschinski R, Rial Saborido J, Böttcher M, Kahlfuss S, Mougiakakos D. Böttcher-Loschinski R, et al. Biomolecules. 2022 Aug 25;12(9):1182. doi: 10.3390/biom12091182. Biomolecules. 2022. PMID: 36139021 Free PMC article. Review.