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Synergistic lethality in chronic myeloid leukemia - targeting oxidative phosphorylation and unfolded protein response effectively complements tyrosine kinase inhibitor treatment.
BMC Cancer. 2023 Nov 27;23(1):1153. doi: 10.1186/s12885-023-11623-6.
BMC Cancer. 2023.
PMID: 38012567
Free PMC article.
Accumulation of T-cell-suppressive PD-L1high extracellular vesicles is associated with GvHD and might impact GvL efficacy.
Baur R, Karl F, Böttcher-Loschinski R, Stoll A, Völkl S, Gießl A, Flamann C, Bruns H, Schlötzer-Schrehardt U, Böttcher M, Schewe DM, Fischer T, Jitschin R, Mackensen A, Mougiakakos D.
Baur R, et al. Among authors: bottcher loschinski r.
J Immunother Cancer. 2023 Mar;11(3):e006362. doi: 10.1136/jitc-2022-006362.
J Immunother Cancer. 2023.
PMID: 36898735
Free PMC article.
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TIGIT signaling and its influence on T cell metabolism and immune cell function in the tumor microenvironment.
Jantz-Naeem N, Böttcher-Loschinski R, Borucki K, Mitchell-Flack M, Böttcher M, Schraven B, Mougiakakos D, Kahlfuss S.
Jantz-Naeem N, et al. Among authors: bottcher loschinski r.
Front Oncol. 2023 Feb 17;13:1060112. doi: 10.3389/fonc.2023.1060112. eCollection 2023.
Front Oncol. 2023.
PMID: 36874131
Free PMC article.
Review.
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Oxidative DNA damage in reconstituting T cells is associated with relapse and inferior survival after allo-SCT.
Karl F, Liang C, Böttcher-Loschinski R, Stoll A, Flamann C, Richter S, Lischer C, Völkl S, Jacobs B, Böttcher M, Jitschin R, Bruns H, Fischer T, Holler E, Rösler W, Dandekar T, Mackensen A, Mougiakakos D.
Karl F, et al. Among authors: bottcher loschinski r.
Blood. 2023 Mar 30;141(13):1626-1639. doi: 10.1182/blood.2022017267.
Blood. 2023.
PMID: 36564029
Free article.
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Lipotoxicity as a Barrier for T Cell-Based Therapies.
Böttcher-Loschinski R, Rial Saborido J, Böttcher M, Kahlfuss S, Mougiakakos D.
Böttcher-Loschinski R, et al.
Biomolecules. 2022 Aug 25;12(9):1182. doi: 10.3390/biom12091182.
Biomolecules. 2022.
PMID: 36139021
Free PMC article.
Review.
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CLL-Derived Extracellular Vesicles Impair T-Cell Activation and Foster T-Cell Exhaustion via Multiple Immunological Checkpoints.
Böttcher M, Böttcher-Loschinski R, Kahlfuss S, Aigner M, Gießl A, Mackensen A, Schlötzer-Schrehardt U, Tüting T, Bruns H, Mougiakakos D.
Böttcher M, et al. Among authors: bottcher loschinski r.
Cells. 2022 Jul 12;11(14):2176. doi: 10.3390/cells11142176.
Cells. 2022.
PMID: 35883619
Free PMC article.
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IL-3 is essential for ICOS-L stabilization on mast cells, and sustains the IL-33-induced RORγt+ Treg generation via enhanced IL-6 induction.
Drube S, Müller S, Weber F, Wegner P, Böttcher-Loschinski R, Gaestel M, Hutloff A, Kamradt T, Andreas N.
Drube S, et al. Among authors: bottcher loschinski r.
Immunology. 2021 May;163(1):86-97. doi: 10.1111/imm.13305. Epub 2021 Jan 27.
Immunology. 2021.
PMID: 33427298
Free PMC article.
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Impact of Nrf2 expression in reconstituting T-cells of allogeneic hematopoietic stem cell transplanted patients.
Karl F, Stoll A, Böttcher-Loschinski R, Böttcher M, Baur R, Jacobs B, Völkl S, Jitschin R, Rösler W, Mackensen A, Mougiakakos D.
Karl F, et al. Among authors: bottcher loschinski r.
Leukemia. 2021 Mar;35(3):910-915. doi: 10.1038/s41375-020-0956-0. Epub 2020 Jul 23.
Leukemia. 2021.
PMID: 32704160
No abstract available.
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