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The MscS-like channel YnaI has a gating mechanism based on flexible pore helices.
Flegler VJ, Rasmussen A, Rao S, Wu N, Zenobi R, Sansom MSP, Hedrich R, Rasmussen T, Böttcher B. Flegler VJ, et al. Among authors: bottcher b. Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):28754-28762. doi: 10.1073/pnas.2005641117. Epub 2020 Nov 4. Proc Natl Acad Sci U S A. 2020. PMID: 33148804 Free PMC article.
More Than Just Closed and Open: Unraveling a Mechanosensor.
Flegler VJ, Rasmussen T, Böttcher B. Flegler VJ, et al. Among authors: bottcher b. Trends Biochem Sci. 2021 Aug;46(8):623-625. doi: 10.1016/j.tibs.2021.04.002. Epub 2021 Apr 17. Trends Biochem Sci. 2021. PMID: 33879366
Mechanosensitive channel gating by delipidation.
Flegler VJ, Rasmussen A, Borbil K, Boten L, Chen HA, Deinlein H, Halang J, Hellmanzik K, Löffler J, Schmidt V, Makbul C, Kraft C, Hedrich R, Rasmussen T, Böttcher B. Flegler VJ, et al. Among authors: bottcher b. Proc Natl Acad Sci U S A. 2021 Aug 17;118(33):e2107095118. doi: 10.1073/pnas.2107095118. Proc Natl Acad Sci U S A. 2021. PMID: 34376558 Free PMC article.
Concentration and composition dependent aggregation of Pluronic- and Poly-(2-oxazolin)-Efavirenz formulations in biorelevant media.
Endres S, Karaev E, Hanio S, Schlauersbach J, Kraft C, Rasmussen T, Luxenhofer R, Böttcher B, Meinel L, Pöppler AC. Endres S, et al. Among authors: bottcher b. J Colloid Interface Sci. 2022 Jan 15;606(Pt 2):1179-1192. doi: 10.1016/j.jcis.2021.08.040. Epub 2021 Aug 10. J Colloid Interface Sci. 2022. PMID: 34487937 Free article.
Biological Activity In Vitro, Absorption, BBB Penetration, and Tolerability of Nanoformulation of BT44:RET Agonist with Disease-Modifying Potential for the Treatment of Neurodegeneration.
Haider MS, Mahato AK, Kotliarova A, Forster S, Böttcher B, Stahlhut P, Sidorova Y, Luxenhofer R. Haider MS, et al. Among authors: bottcher b. Biomacromolecules. 2023 Oct 9;24(10):4348-4365. doi: 10.1021/acs.biomac.2c00761. Epub 2022 Oct 11. Biomacromolecules. 2023. PMID: 36219820 Free PMC article.
217 results