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The reason for the low Ca2+-sensitivity of thin filaments associated with the Glu41Lys mutation in the TPM2 gene is "freezing" of tropomyosin near the outer domain of actin and inhibition of actin monomer switching off during the ATPase cycle.
Avrova SV, Karpicheva OE, Rysev NA, Simonyan AO, Sirenko VV, Redwood CS, Borovikov YS. Avrova SV, et al. Biochem Biophys Res Commun. 2018 Jul 12;502(2):209-214. doi: 10.1016/j.bbrc.2018.05.145. Epub 2018 May 26. Biochem Biophys Res Commun. 2018. PMID: 29792862
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