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Inhibiting de novo ceramide synthesis restores mitochondrial and protein homeostasis in muscle aging.
Lima TI, Laurila PP, Wohlwend M, Morel JD, Goeminne LJE, Li H, Romani M, Li X, Oh CM, Park D, Rodríguez-López S, Ivanisevic J, Gallart-Ayala H, Crisol B, Delort F, Batonnet-Pichon S, Silveira LR, Sankabattula Pavani Veera Venkata L, Padala AK, Jain S, Auwerx J. Lima TI, et al. Among authors: auwerx j. Sci Transl Med. 2023 May 17;15(696):eade6509. doi: 10.1126/scitranslmed.ade6509. Epub 2023 May 17. Sci Transl Med. 2023. PMID: 37196064
Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity.
Sorrentino V, Romani M, Mouchiroud L, Beck JS, Zhang H, D'Amico D, Moullan N, Potenza F, Schmid AW, Rietsch S, Counts SE, Auwerx J. Sorrentino V, et al. Among authors: auwerx j. Nature. 2017 Dec 14;552(7684):187-193. doi: 10.1038/nature25143. Epub 2017 Dec 6. Nature. 2017. PMID: 29211722 Free PMC article.
De novo NAD+ synthesis enhances mitochondrial function and improves health.
Katsyuba E, Mottis A, Zietak M, De Franco F, van der Velpen V, Gariani K, Ryu D, Cialabrini L, Matilainen O, Liscio P, Giacchè N, Stokar-Regenscheit N, Legouis D, de Seigneux S, Ivanisevic J, Raffaelli N, Schoonjans K, Pellicciari R, Auwerx J. Katsyuba E, et al. Among authors: auwerx j. Nature. 2018 Nov;563(7731):354-359. doi: 10.1038/s41586-018-0645-6. Epub 2018 Oct 24. Nature. 2018. PMID: 30356218 Free PMC article.
The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging.
D'Amico D, Mottis A, Potenza F, Sorrentino V, Li H, Romani M, Lemos V, Schoonjans K, Zamboni N, Knott G, Schneider BL, Auwerx J. D'Amico D, et al. Among authors: auwerx j. Mol Cell. 2019 Feb 21;73(4):775-787.e10. doi: 10.1016/j.molcel.2018.11.034. Epub 2019 Jan 11. Mol Cell. 2019. PMID: 30642763 Free PMC article.
Niacin: an old lipid drug in a new NAD+ dress.
Romani M, Hofer DC, Katsyuba E, Auwerx J. Romani M, et al. Among authors: auwerx j. J Lipid Res. 2019 Apr;60(4):741-746. doi: 10.1194/jlr.S092007. Epub 2019 Feb 19. J Lipid Res. 2019. PMID: 30782960 Free PMC article.
Cross-species functional modules link proteostasis to human normal aging.
Komljenovic A, Li H, Sorrentino V, Kutalik Z, Auwerx J, Robinson-Rechavi M. Komljenovic A, et al. Among authors: auwerx j. PLoS Comput Biol. 2019 Jul 3;15(7):e1007162. doi: 10.1371/journal.pcbi.1007162. eCollection 2019 Jul. PLoS Comput Biol. 2019. PMID: 31269015 Free PMC article.
Opposing action of NCoR1 and PGC-1α in mitochondrial redox homeostasis.
Lima TI, Guimarães DSPSF, Oliveira AG, Araujo H, Sponton CHG, Souza-Pinto NC, Saito Â, Figueira ACM, Palameta S, Bajgelman MC, Calixto A, Pinto S, Mori MA, Orofino J, Perissi V, Mottis A, Auwerx J, Silveira LR. Lima TI, et al. Among authors: auwerx j. Free Radic Biol Med. 2019 Nov 1;143:203-208. doi: 10.1016/j.freeradbiomed.2019.08.006. Epub 2019 Aug 10. Free Radic Biol Med. 2019. PMID: 31408725
Mouse Systems Genetics as a Prelude to Precision Medicine.
Li H, Auwerx J. Li H, et al. Among authors: auwerx j. Trends Genet. 2020 Apr;36(4):259-272. doi: 10.1016/j.tig.2020.01.004. Epub 2020 Feb 6. Trends Genet. 2020. PMID: 32037011 Free PMC article. Review.
Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism.
Williams K, Ingerslev LR, Bork-Jensen J, Wohlwend M, Hansen AN, Small L, Ribel-Madsen R, Astrup A, Pedersen O, Auwerx J, Workman CT, Grarup N, Hansen T, Barrès R. Williams K, et al. Among authors: auwerx j. Nat Commun. 2020 Jun 1;11(1):2695. doi: 10.1038/s41467-020-16537-6. Nat Commun. 2020. PMID: 32483258 Free PMC article.
626 results