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The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice.
Engle DD, Tiriac H, Rivera KD, Pommier A, Whalen S, Oni TE, Alagesan B, Lee EJ, Yao MA, Lucito MS, Spielman B, Da Silva B, Schoepfer C, Wright K, Creighton B, Afinowicz L, Yu KH, Grützmann R, Aust D, Gimotty PA, Pollard KS, Hruban RH, Goggins MG, Pilarsky C, Park Y, Pappin DJ, Hollingsworth MA, Tuveson DA. Engle DD, et al. Among authors: aust d. Science. 2019 Jun 21;364(6446):1156-1162. doi: 10.1126/science.aaw3145. Science. 2019. PMID: 31221853 Free PMC article.
The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma.
Pérez-Mancera PA, Rust AG, van der Weyden L, Kristiansen G, Li A, Sarver AL, Silverstein KA, Grützmann R, Aust D, Rümmele P, Knösel T, Herd C, Stemple DL, Kettleborough R, Brosnan JA, Li A, Morgan R, Knight S, Yu J, Stegeman S, Collier LS, ten Hoeve JJ, de Ridder J, Klein AP, Goggins M, Hruban RH, Chang DK, Biankin AV, Grimmond SM; Australian Pancreatic Cancer Genome Initiative; Wessels LF, Wood SA, Iacobuzio-Donahue CA, Pilarsky C, Largaespada DA, Adams DJ, Tuveson DA. Pérez-Mancera PA, et al. Among authors: aust d. Nature. 2012 Apr 29;486(7402):266-70. doi: 10.1038/nature11114. Nature. 2012. PMID: 22699621 Free PMC article.
Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor β signaling.
Weissmueller S, Manchado E, Saborowski M, Morris JP 4th, Wagenblast E, Davis CA, Moon SH, Pfister NT, Tschaharganeh DF, Kitzing T, Aust D, Markert EK, Wu J, Grimmond SM, Pilarsky C, Prives C, Biankin AV, Lowe SW. Weissmueller S, et al. Among authors: aust d. Cell. 2014 Apr 10;157(2):382-394. doi: 10.1016/j.cell.2014.01.066. Cell. 2014. PMID: 24725405 Free PMC article.
229 results