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C3aR and C5aR1 act as key regulators of human and mouse β-cell function.
Atanes P, Ruz-Maldonado I, Pingitore A, Hawkes R, Liu B, Zhao M, Huang GC, Persaud SJ, Amisten S. Atanes P, et al. Among authors: pingitore a. Cell Mol Life Sci. 2018 Feb;75(4):715-726. doi: 10.1007/s00018-017-2655-1. Epub 2017 Sep 18. Cell Mol Life Sci. 2018. PMID: 28921001 Free PMC article.
The diet-derived short chain fatty acid propionate improves beta-cell function in humans and stimulates insulin secretion from human islets in vitro.
Pingitore A, Chambers ES, Hill T, Maldonado IR, Liu B, Bewick G, Morrison DJ, Preston T, Wallis GA, Tedford C, Castañera González R, Huang GC, Choudhary P, Frost G, Persaud SJ. Pingitore A, et al. Diabetes Obes Metab. 2017 Feb;19(2):257-265. doi: 10.1111/dom.12811. Epub 2016 Nov 23. Diabetes Obes Metab. 2017. PMID: 27761989
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