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Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection.
Wei G, Iqbal N, Courouble VV, Francis AC, Singh PK, Hudait A, Annamalai AS, Bester S, Huang SW, Shkriabai N, Briganti L, Haney R, KewalRamani VN, Voth GA, Engelman AN, Melikyan GB, Griffin PR, Asturias F, Kvaratskhelia M. Wei G, et al. Among authors: asturias f. Nat Commun. 2022 Oct 6;13(1):5879. doi: 10.1038/s41467-022-33662-6. Nat Commun. 2022. PMID: 36202818 Free PMC article.
Structural and mechanistic bases for a potent HIV-1 capsid inhibitor.
Bester SM, Wei G, Zhao H, Adu-Ampratwum D, Iqbal N, Courouble VV, Francis AC, Annamalai AS, Singh PK, Shkriabai N, Van Blerkom P, Morrison J, Poeschla EM, Engelman AN, Melikyan GB, Griffin PR, Fuchs JR, Asturias FJ, Kvaratskhelia M. Bester SM, et al. Among authors: asturias fj. Science. 2020 Oct 16;370(6514):360-364. doi: 10.1126/science.abb4808. Science. 2020. PMID: 33060363 Free PMC article.
Mediator structure and rearrangements required for holoenzyme formation.
Tsai KL, Yu X, Gopalan S, Chao TC, Zhang Y, Florens L, Washburn MP, Murakami K, Conaway RC, Conaway JW, Asturias FJ. Tsai KL, et al. Among authors: asturias fj. Nature. 2017 Apr 13;544(7649):196-201. doi: 10.1038/nature21393. Epub 2017 Mar 1. Nature. 2017. PMID: 28241144 Free PMC article.
Architecture of the Mediator head module.
Imasaki T, Calero G, Cai G, Tsai KL, Yamada K, Cardelli F, Erdjument-Bromage H, Tempst P, Berger I, Kornberg GL, Asturias FJ, Kornberg RD, Takagi Y. Imasaki T, et al. Among authors: asturias fj. Nature. 2011 Jul 3;475(7355):240-3. doi: 10.1038/nature10162. Nature. 2011. PMID: 21725323 Free PMC article.
A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers.
El Khattabi L, Zhao H, Kalchschmidt J, Young N, Jung S, Van Blerkom P, Kieffer-Kwon P, Kieffer-Kwon KR, Park S, Wang X, Krebs J, Tripathi S, Sakabe N, Sobreira DR, Huang SC, Rao SSP, Pruett N, Chauss D, Sadler E, Lopez A, Nóbrega MA, Aiden EL, Asturias FJ, Casellas R. El Khattabi L, et al. Among authors: asturias fj. Cell. 2019 Aug 22;178(5):1145-1158.e20. doi: 10.1016/j.cell.2019.07.011. Epub 2019 Aug 8. Cell. 2019. PMID: 31402173 Free PMC article.
Mediator head module structure and functional interactions.
Cai G, Imasaki T, Yamada K, Cardelli F, Takagi Y, Asturias FJ. Cai G, et al. Among authors: asturias fj. Nat Struct Mol Biol. 2010 Mar;17(3):273-9. doi: 10.1038/nsmb.1757. Epub 2010 Feb 14. Nat Struct Mol Biol. 2010. PMID: 20154708 Free PMC article.
Interaction of the mediator head module with RNA polymerase II.
Cai G, Chaban YL, Imasaki T, Kovacs JA, Calero G, Penczek PA, Takagi Y, Asturias FJ. Cai G, et al. Structure. 2012 May 9;20(5):899-910. doi: 10.1016/j.str.2012.02.023. Structure. 2012. PMID: 22579255 Free PMC article.
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