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Botryosphaeran, [(1 → 3)(1 → 6)-β-D-glucan], induces apoptosis-like death in promastigotes of Leishmania amazonensis, and exerts a leishmanicidal effect on infected macrophages by activating NF-kB and producing pro-inflammatory molecules.
Carloto ACM, Bortoleti BTDS, Rodrigues ACJ, Silva TF, Tomiotto-Pellissier F, Bidóia DL, Gonçalves MD, Assolini JP, Dekker RFH, Barbosa-Dekker AM, Costa IN, Conchon-Costa I, Miranda-Sapla MM, Pavanelli WR. Carloto ACM, et al. Among authors: assolini jp. Chem Biol Interact. 2022 Jan 5;351:109713. doi: 10.1016/j.cbi.2021.109713. Epub 2021 Oct 23. Chem Biol Interact. 2022. PMID: 34699765
Diethyldithiocarbamate encapsulation reduces toxicity and promotes leishmanicidal effect through apoptosis-like mechanism in promastigote and ROS production by macrophage.
Assolini JP, Tomiotto-Pellissier F, da Silva Bortoleti BT, Gonçalves MD, Sahd CS, Carloto ACM, Feuser PE, Cordeiro AP, Borghi SM, Verri WA Jr, Sayer C, Hermes de Araújo PH, Costa IN, Conchon-Costa I, Miranda-Sapla MM, Pavanelli WR. Assolini JP, et al. J Drug Target. 2020 Dec;28(10):1110-1123. doi: 10.1080/1061186X.2020.1783669. Epub 2020 Jun 30. J Drug Target. 2020. PMID: 32546016
Caryocar coriaceum extracts exert leishmanicidal effect acting in promastigote forms by apoptosis-like mechanism and intracellular amastigotes by Nrf2/HO-1/ferritin dependent response and iron depletion: Leishmanicidal effect of Caryocar coriaceum leaf exracts.
Tomiotto-Pellissier F, Alves DR, Miranda-Sapla MM, de Morais SM, Assolini JP, da Silva Bortoleti BT, Gonçalves MD, Cataneo AHD, Kian D, Madeira TB, Yamauchi LM, Nixdorf SL, Costa IN, Conchon-Costa I, Pavanelli WR. Tomiotto-Pellissier F, et al. Among authors: assolini jp. Biomed Pharmacother. 2018 Feb;98:662-672. doi: 10.1016/j.biopha.2017.12.083. Epub 2018 Jan 4. Biomed Pharmacother. 2018. PMID: 29294453
Dehydroabietic acid isolated from Pinus elliottii exerts in vitro antileishmanial action by pro-oxidant effect, inducing ROS production in promastigote and downregulating Nrf2/ferritin expression in amastigote forms of Leishmania amazonensis.
Gonçalves MD, Bortoleti BTS, Tomiotto-Pellissier F, Miranda-Sapla MM, Assolini JP, Carloto ACM, Carvalho PGC, Tudisco ET, Urbano A, Ambrósio SR, Hirooka EY, Simão ANC, Costa IN, Pavanelli WR, Conchon-Costa I, Arakawa NS. Gonçalves MD, et al. Among authors: assolini jp. Fitoterapia. 2018 Jul;128:224-232. doi: 10.1016/j.fitote.2018.05.027. Epub 2018 May 23. Fitoterapia. 2018. PMID: 29802873
Grandiflorenic acid promotes death of promastigotes via apoptosis-like mechanism and affects amastigotes by increasing total iron bound capacity.
Bortoleti BTDS, Gonçalves MD, Tomiotto-Pellissier F, Miranda-Sapla MM, Assolini JP, Carloto ACM, de Carvalho PGC, Cardoso ILA, Simão ANC, Arakawa NS, Costa IN, Conchon-Costa I, Pavanelli WR. Bortoleti BTDS, et al. Among authors: assolini jp. Phytomedicine. 2018 Jul 15;46:11-20. doi: 10.1016/j.phymed.2018.06.010. Epub 2018 Jun 13. Phytomedicine. 2018. PMID: 30097110
Caffeic acid has antipromastigote activity by apoptosis-like process; and anti-amastigote by TNF-α/ROS/NO production and decreased of iron availability.
Bortoleti BTDS, Tomiotto-Pellissier F, Gonçalves MD, Miranda-Sapla MM, Assolini JP, Carloto AC, Lima DM, Silveira GF, Almeida RS, Costa IN, Conchon-Costa I, Pavanelli WR. Bortoleti BTDS, et al. Among authors: assolini jp. Phytomedicine. 2019 Apr;57:262-270. doi: 10.1016/j.phymed.2018.12.035. Epub 2018 Dec 31. Phytomedicine. 2019. PMID: 30802712
Quercetin promotes antipromastigote effect by increasing the ROS production and anti-amastigote by upregulating Nrf2/HO-1 expression, affecting iron availability.
Cataneo AHD, Tomiotto-Pellissier F, Miranda-Sapla MM, Assolini JP, Panis C, Kian D, Yamauchi LM, Colado Simão AN, Casagrande R, Pinge-Filho P, Costa IN, Verri WA Jr, Conchon-Costa I, Pavanelli WR. Cataneo AHD, et al. Among authors: assolini jp. Biomed Pharmacother. 2019 May;113:108745. doi: 10.1016/j.biopha.2019.108745. Epub 2019 Mar 2. Biomed Pharmacother. 2019. PMID: 30836276 Free article.
trans-Chalcone modulates Leishmania amazonensis infection in vitro by Nrf2 overexpression affecting iron availability.
Miranda-Sapla MM, Tomiotto-Pellissier F, Assolini JP, Carloto ACM, Bortoleti BTDS, Gonçalves MD, Tavares ER, Rodrigues JHDS, Simão ANC, Yamauchi LM, Nakamura CV, Verri WA Jr, Costa IN, Conchon-Costa I, Pavanelli WR. Miranda-Sapla MM, et al. Among authors: assolini jp. Eur J Pharmacol. 2019 Jun 15;853:275-288. doi: 10.1016/j.ejphar.2019.03.049. Epub 2019 Apr 6. Eur J Pharmacol. 2019. PMID: 30965057
4-nitrochalcone exerts leishmanicidal effect on L. amazonensis promastigotes and intracellular amastigotes, and the 4-nitrochalcone encapsulation in beeswax copaiba oil nanoparticles reduces macrophages cytotoxicity.
Assolini JP, da Silva TP, da Silva Bortoleti BT, Gonçalves MD, Tomiotto-Pellissier F, Sahd CS, Carloto ACM, Feuser PE, Cordeiro AP, Sayer C, Hermes de Araújo PH, Costa IN, Conchon-Costa I, Miranda-Sapla MM, Pavanelli WR. Assolini JP, et al. Eur J Pharmacol. 2020 Oct 5;884:173392. doi: 10.1016/j.ejphar.2020.173392. Epub 2020 Jul 28. Eur J Pharmacol. 2020. PMID: 32735985 Free article.
Investigation of the antileishmanial activity and mechanisms of action of acetyl-thiohydantoins.
Bortoleti BTDS, Gonçalves MD, Tomiotto-Pellissier F, Camargo PG, Assolini JP, Concato VM, Detoni MB, Bidóia DL, Bispo MLF, Lima CHDS, de Macedo FC Jr, Conchon-Costa I, Miranda-Sapla MM, Wowk PF, Pavanelli WR. Bortoleti BTDS, et al. Among authors: assolini jp. Chem Biol Interact. 2022 Jan 5;351:109690. doi: 10.1016/j.cbi.2021.109690. Epub 2021 Oct 9. Chem Biol Interact. 2022. PMID: 34637778
29 results