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Decreased percentages of plasmacytoid dendritic cells predict survival in critically ill patients.
Steinacher E, Lenz M, Krychtiuk KA, Hengstenberg C, Huber K, Wojta J, Heinz G, Niessner A, Speidl WS, Koller L. Steinacher E, et al. J Leukoc Biol. 2024 Apr 29;115(5):902-912. doi: 10.1093/jleuko/qiae003. J Leukoc Biol. 2024. PMID: 38180532
The aim of this study was to analyze whether DCs or their respective subsets are associated with 30-d mortality in an unselected patient cohort admitted to a medical ICU with a cardiovascular focus. ...In the total cohort, low percentages of DCs were significantly assoc
The aim of this study was to analyze whether DCs or their respective subsets are associated with 30-d mortality in an unselected pati …
Basic mechanisms in cardiogenic shock: part 2 - biomarkers and treatment options.
Krychtiuk KA, Vrints C, Wojta J, Huber K, Speidl WS. Krychtiuk KA, et al. Eur Heart J Acute Cardiovasc Care. 2022 Jun 7;11(4):366-374. doi: 10.1093/ehjacc/zuac022. Eur Heart J Acute Cardiovasc Care. 2022. PMID: 35218355
Within Part 2 of this two-part educational review on basic mechanisms in cardiogenic shock, we aimed to highlight the current status of translating our understanding of the pathophysiology of cardiogenic shock into clinical practice. We summarize the current status of biomarker …
Within Part 2 of this two-part educational review on basic mechanisms in cardiogenic shock, we aimed to highlight the current status of tran …
Impact of platelet turnover on long-term adverse cardiovascular outcomes in patients undergoing percutaneous coronary intervention.
Tscharre M, Farhan S, Bruno V, Rohla M, Egger F, Weiss TW, Hübl W, Willheim M, Wojta J, Geppert A, Huber K, Freynhofer MK. Tscharre M, et al. Eur J Clin Invest. 2019 Sep;49(9):e13157. doi: 10.1111/eci.13157. Epub 2019 Aug 19. Eur J Clin Invest. 2019. PMID: 31318979
After adjustment, continuous RPC (HR 1.055 [95%CI 1.012-1.099]; P = .010) and dichotomized RPC (HR 1.716 [95%CI 1.152-2.559]; P = .007) remained significantly associated with MACE. Neither MPV nor platelet function testing was associated with long-term adverse outco …
After adjustment, continuous RPC (HR 1.055 [95%CI 1.012-1.099]; P = .010) and dichotomized RPC (HR 1.716 [95%CI 1.152-2.559]; P = .007) rema …
Course of platelet miRNAs after cessation of P2Y12 antagonists.
Jäger B, Stojkovic S, Haller PM, Piackova E, Kahl BS, Andric T, Vargas KG, Wojta J, Huber K. Jäger B, et al. Eur J Clin Invest. 2019 Aug;49(8):e13149. doi: 10.1111/eci.13149. Epub 2019 Jun 23. Eur J Clin Invest. 2019. PMID: 31172515

After adjustment for confounders, choice of P2Y12-inhibitor was the strongest predictor of miRNA levels (P < 0.001), while cessation of P2Y12-inhibitor therapy did not significantly impact miRNA levels. CONCLUSION: In patients with CAD, ticagrelor intake is associated w

After adjustment for confounders, choice of P2Y12-inhibitor was the strongest predictor of miRNA levels (P < 0.001), while cessation of P