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CD4+ T cell calibration of antigen-presenting cells optimizes antiviral CD8+ T cell immunity.
Gressier E, Schulte-Schrepping J, Petrov L, Brumhard S, Stubbemann P, Hiller A, Obermayer B, Spitzer J, Kostevc T, Whitney PG, Bachem A, Odainic A, van de Sandt C, Nguyen THO, Ashhurst T, Wilson K, Oates CVL, Gearing LJ, Meischel T, Hochheiser K, Greyer M, Clarke M, Kreutzenbeck M, Gabriel SS, Kastenmüller W, Kurts C, Londrigan SL, Kallies A, Kedzierska K, Hertzog PJ, Latz E, Chen YE, Radford KJ, Chopin M, Schroeder J, Kurth F, Gebhardt T, Sander LE, Sawitzki B, Schultze JL, Schmidt SV, Bedoui S. Gressier E, et al. Among authors: ashhurst t. Nat Immunol. 2023 Jun;24(6):979-990. doi: 10.1038/s41590-023-01517-x. Epub 2023 May 15. Nat Immunol. 2023. PMID: 37188942
Integrated immune dynamics define correlates of COVID-19 severity and antibody responses.
Koutsakos M, Rowntree LC, Hensen L, Chua BY, van de Sandt CE, Habel JR, Zhang W, Jia X, Kedzierski L, Ashhurst TM, Putri GH, Marsh-Wakefield F, Read MN, Edwards DN, Clemens EB, Wong CY, Mordant FL, Juno JA, Amanat F, Audsley J, Holmes NE, Gordon CL, Smibert OC, Trubiano JA, Hughes CM, Catton M, Denholm JT, Tong SYC, Doolan DL, Kotsimbos TC, Jackson DC, Krammer F, Godfrey DI, Chung AW, King NJC, Lewin SR, Wheatley AK, Kent SJ, Subbarao K, McMahon J, Thevarajan I, Nguyen THO, Cheng AC, Kedzierska K. Koutsakos M, et al. Among authors: ashhurst tm. Cell Rep Med. 2021 Mar 16;2(3):100208. doi: 10.1016/j.xcrm.2021.100208. Epub 2021 Feb 5. Cell Rep Med. 2021. PMID: 33564749 Free PMC article.
SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severity.
Zhang W, Chua BY, Selva KJ, Kedzierski L, Ashhurst TM, Haycroft ER, Shoffner-Beck SK, Hensen L, Boyd DF, James F, Mouhtouris E, Kwong JC, Chua KYL, Drewett G, Copaescu A, Dobson JE, Rowntree LC, Habel JR, Allen LF, Koay HF, Neil JA, Gartner MJ, Lee CY, Andersson P, Khan SF, Blakeway L, Wisniewski J, McMahon JH, Vine EE, Cunningham AL, Audsley J, Thevarajan I, Seemann T, Sherry NL, Amanat F, Krammer F, Londrigan SL, Wakim LM, King NJC, Godfrey DI, Mackay LK, Thomas PG, Nicholson S, Arnold KB, Chung AW, Holmes NE, Smibert OC, Trubiano JA, Gordon CL, Nguyen THO, Kedzierska K. Zhang W, et al. Among authors: ashhurst tm. Nat Commun. 2022 May 19;13(1):2774. doi: 10.1038/s41467-022-30088-y. Nat Commun. 2022. PMID: 35589689 Free PMC article.
Immune dynamics in SARS-CoV-2 experienced immunosuppressed rheumatoid arthritis or multiple sclerosis patients vaccinated with mRNA-1273.
Verstegen NJM, Hagen RR, van den Dijssel J, Kuijper LH, Kreher C, Ashhurst T, Kummer LYL, Steenhuis M, Duurland M, de Jongh R, de Jong N, van der Schoot CE, Bos AV, Mul E, Kedzierska K, van Dam KPJ, Stalman EW, Boekel L, Wolbink G, Tas SW, Killestein J, van Kempen ZLE, Wieske L, Kuijpers TW, Eftimov F, Rispens T, van Ham SM, Ten Brinke A, van de Sandt CE; T2B! immunity against SARS-CoV-2 study group. Verstegen NJM, et al. Among authors: ashhurst t. Elife. 2022 Jul 15;11:e77969. doi: 10.7554/eLife.77969. Elife. 2022. PMID: 35838348 Free PMC article.
Circulating effector γδ T cell populations are associated with acute coronavirus disease 19 in unvaccinated individuals.
von Borstel A, Nguyen TH, Rowntree LC, Ashhurst TM, Allen LF, Howson LJ, Holmes NE, Smibert OC, Trubiano JA, Gordon CL, Cheng AC, Kent SJ, Rossjohn J, Kedzierska K, Davey MS. von Borstel A, et al. Among authors: ashhurst tm. Immunol Cell Biol. 2023 Apr;101(4):321-332. doi: 10.1111/imcb.12623. Epub 2023 Feb 19. Immunol Cell Biol. 2023. PMID: 36698330
A high-dimensional cytometry atlas of peripheral blood over the human life span.
Jalali S, Harpur CM, Piers AT, Auladell M, Perriman L, Li S, An K, Anderson J, Berzins SP, Licciardi PV, Ashhurst TM, Konstantinov IE, Pellicci DG. Jalali S, et al. Among authors: ashhurst tm. Immunol Cell Biol. 2022 Nov;100(10):805-821. doi: 10.1111/imcb.12594. Epub 2022 Nov 6. Immunol Cell Biol. 2022. PMID: 36218032 Free PMC article.
IRF9 Prevents CD8+ T Cell Exhaustion in an Extrinsic Manner during Acute Lymphocytic Choriomeningitis Virus Infection.
Huber M, Suprunenko T, Ashhurst T, Marbach F, Raifer H, Wolff S, Strecker T, Viengkhou B, Jung SR, Obermann HL, Bauer S, Xu HC, Lang PA, Tom A, Lang KS, King NJC, Campbell IL, Hofer MJ. Huber M, et al. Among authors: ashhurst t. J Virol. 2017 Oct 27;91(22):e01219-17. doi: 10.1128/JVI.01219-17. Print 2017 Nov 15. J Virol. 2017. PMID: 28878077 Free PMC article.
40 results