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Synthetic reversed sequences reveal default genomic states.
Camellato BR, Brosh R, Ashe HJ, Maurano MT, Boeke JD. Camellato BR, et al. Among authors: ashe hj. Nature. 2024 Apr;628(8007):373-380. doi: 10.1038/s41586-024-07128-2. Epub 2024 Mar 6. Nature. 2024. PMID: 38448583 Free PMC article.
On the genetic basis of tail-loss evolution in humans and apes.
Xia B, Zhang W, Zhao G, Zhang X, Bai J, Brosh R, Wudzinska A, Huang E, Ashe H, Ellis G, Pour M, Zhao Y, Coelho C, Zhu Y, Miller A, Dasen JS, Maurano MT, Kim SY, Boeke JD, Yanai I. Xia B, et al. Among authors: ashe h. Nature. 2024 Feb;626(8001):1042-1048. doi: 10.1038/s41586-024-07095-8. Epub 2024 Feb 28. Nature. 2024. PMID: 38418917 Free PMC article.
Mouse genome rewriting and tailoring of three important disease loci.
Zhang W, Golynker I, Brosh R, Fajardo A, Zhu Y, Wudzinska AM, Ordoñez R, Ribeiro-Dos-Santos AM, Carrau L, Damani-Yokota P, Yeung ST, Khairallah C, Vela Gartner A, Chalhoub N, Huang E, Ashe HJ, Khanna KM, Maurano MT, Kim SY, tenOever BR, Boeke JD. Zhang W, et al. Among authors: ashe hj. Nature. 2023 Nov;623(7986):423-431. doi: 10.1038/s41586-023-06675-4. Epub 2023 Nov 1. Nature. 2023. PMID: 37914927 Free PMC article.
Genomic context sensitizes regulatory elements to genetic disruption.
Ordoñez R, Zhang W, Ellis G, Zhu Y, Ashe HJ, Ribeiro-Dos-Santos AM, Brosh R, Huang E, Hogan MS, Boeke JD, Maurano MT. Ordoñez R, et al. Among authors: ashe hj. bioRxiv [Preprint]. 2024 Mar 12:2023.07.02.547201. doi: 10.1101/2023.07.02.547201. bioRxiv. 2024. PMID: 37781588 Free PMC article. Preprint.
Synthetic regulatory genomics uncovers enhancer context dependence at the Sox2 locus.
Brosh R, Coelho C, Ribeiro-Dos-Santos AM, Ellis G, Hogan MS, Ashe HJ, Somogyi N, Ordoñez R, Luther RD, Huang E, Boeke JD, Maurano MT. Brosh R, et al. Among authors: ashe hj. Mol Cell. 2023 Apr 6;83(7):1140-1152.e7. doi: 10.1016/j.molcel.2023.02.027. Epub 2023 Mar 16. Mol Cell. 2023. PMID: 36931273 Free PMC article.
187 results