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GRK2 Kinases in the Primary Cilium Initiate SMOOTHENED-PKA Signaling in the Hedgehog Cascade.
bioRxiv [Preprint]. 2024 Apr 18:2023.05.10.540226. doi: 10.1101/2023.05.10.540226.
bioRxiv. 2024.
PMID: 37214942
Free PMC article.
Preprint.
A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction.
Happ JT, Arveseth CD, Bruystens J, Bertinetti D, Nelson IB, Olivieri C, Zhang J, Hedeen DS, Zhu JF, Capener JL, Bröckel JW, Vu L, King CC, Ruiz-Perez VL, Ge X, Veglia G, Herberg FW, Taylor SS, Myers BR.
Happ JT, et al. Among authors: arveseth cd.
Nat Struct Mol Biol. 2022 Oct;29(10):990-999. doi: 10.1038/s41594-022-00838-z. Epub 2022 Oct 6.
Nat Struct Mol Biol. 2022.
PMID: 36202993
Free PMC article.
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Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits.
Arveseth CD, Happ JT, Hedeen DS, Zhu JF, Capener JL, Klatt Shaw D, Deshpande I, Liang J, Xu J, Stubben SL, Nelson IB, Walker MF, Kawakami K, Inoue A, Krogan NJ, Grunwald DJ, Hüttenhain R, Manglik A, Myers BR.
Arveseth CD, et al.
PLoS Biol. 2021 Apr 22;19(4):e3001191. doi: 10.1371/journal.pbio.3001191. eCollection 2021 Apr.
PLoS Biol. 2021.
PMID: 33886552
Free PMC article.
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