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Autophagy is a major regulator of beta cell insulin homeostasis.
Riahi Y, Wikstrom JD, Bachar-Wikstrom E, Polin N, Zucker H, Lee MS, Quan W, Haataja L, Liu M, Arvan P, Cerasi E, Leibowitz G. Riahi Y, et al. Among authors: arvan p. Diabetologia. 2016 Jul;59(7):1480-1491. doi: 10.1007/s00125-016-3868-9. Epub 2016 Jan 30. Diabetologia. 2016. PMID: 26831301 Free PMC article.
Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes.
Sims EK, Bahnson HT, Nyalwidhe J, Haataja L, Davis AK, Speake C, DiMeglio LA, Blum J, Morris MA, Mirmira RG, Nadler J, Mastracci TL, Marcovina S, Qian WJ, Yi L, Swensen AC, Yip-Schneider M, Schmidt CM, Considine RV, Arvan P, Greenbaum CJ, Evans-Molina C; T1D Exchange Residual C-peptide Study Group. Sims EK, et al. Among authors: arvan p. Diabetes Care. 2019 Feb;42(2):258-264. doi: 10.2337/dc17-2625. Epub 2018 Dec 10. Diabetes Care. 2019. PMID: 30530850 Free PMC article.
Response to Comment on Sims et al. Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes. Diabetes Care 2019;42:258-264.
Sims EK, Bahnson HT, Nyalwidhe J, Haataja L, Davis AK, Speake C, DiMeglio LA, Blum J, Morris MA, Mirmira RG, Nadler J, Mastracci TL, Marcovina S, Qian WJ, Yi L, Swensen AC, Yip-Schneider M, Schmidt CM, Considine RV, Arvan P, Greenbaum CJ, Evans-Molina C. Sims EK, et al. Among authors: arvan p. Diabetes Care. 2019 May;42(5):e85-e86. doi: 10.2337/dci19-0012. Diabetes Care. 2019. PMID: 31010952 Free PMC article. No abstract available.
Abnormalities in proinsulin processing in islets from individuals with longstanding T1D.
Sims EK, Syed F, Nyalwidhe J, Bahnson HT, Haataja L, Speake C, Morris MA, Balamurugan AN, Mirmira RG, Nadler J, Mastracci TL, Arvan P, Greenbaum CJ, Evans-Molina C. Sims EK, et al. Among authors: arvan p. Transl Res. 2019 Nov;213:90-99. doi: 10.1016/j.trsl.2019.08.001. Epub 2019 Aug 9. Transl Res. 2019. PMID: 31442418 Free PMC article.
Altered β-Cell Prohormone Processing and Secretion in Type 1 Diabetes.
Rodriguez-Calvo T, Chen YC, Verchere CB, Haataja L, Arvan P, Leete P, Richardson SJ, Morgan NG, Qian WJ, Pugliese A, Atkinson M, Evans-Molina C, Sims EK. Rodriguez-Calvo T, et al. Among authors: arvan p. Diabetes. 2021 May;70(5):1038-1050. doi: 10.2337/dbi20-0034. Epub 2021 May 4. Diabetes. 2021. PMID: 33947721 Free PMC article. Review.
The G209R mutant mouse as a model for human PCSK1 polyendocrinopathy.
Shakya M, Gahlot S, Martin NK, Arunagiri A, Martin MG, Arvan P, Low MJ, Lindberg I. Shakya M, et al. Among authors: arvan p. Endocrinology. 2022 Mar 4;163(5):bqac024. doi: 10.1210/endocr/bqac024. Online ahead of print. Endocrinology. 2022. PMID: 35245347 Free PMC article.
Proinsulin folding and trafficking defects trigger a common pathological disturbance of endoplasmic reticulum homeostasis.
Arunagiri A, Alam M, Haataja L, Draz H, Alasad B, Samy P, Sadique N, Tong Y, Cai Y, Shakeri H, Fantuzzi F, Ibrahim H, Jang I, Sidarala V, Soleimanpour SA, Satin LS, Otonkoski T, Cnop M, Itkin-Ansari P, Kaufman RJ, Liu M, Arvan P. Arunagiri A, et al. Among authors: arvan p. Protein Sci. 2024 Apr;33(4):e4949. doi: 10.1002/pro.4949. Protein Sci. 2024. PMID: 38511500 Free PMC article.
210 results