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Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent cognitive impairment in C9orf72 BAC transgenic mice.
Jury N, Abarzua S, Diaz I, Guerra MV, Ampuero E, Cubillos P, Martinez P, Herrera-Soto A, Arredondo C, Rojas F, Manterola M, Rojas A, Montecino M, Varela-Nallar L, van Zundert B. Jury N, et al. Among authors: arredondo c. Clin Epigenetics. 2020 Feb 18;12(1):32. doi: 10.1186/s13148-020-0816-9. Clin Epigenetics. 2020. PMID: 32070418 Free PMC article.
Excessive release of inorganic polyphosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons.
Arredondo C, Cefaliello C, Dyrda A, Jury N, Martinez P, Díaz I, Amaro A, Tran H, Morales D, Pertusa M, Stoica L, Fritz E, Corvalán D, Abarzúa S, Méndez-Ruette M, Fernández P, Rojas F, Kumar MS, Aguilar R, Almeida S, Weiss A, Bustos FJ, González-Nilo F, Otero C, Tevy MF, Bosco DA, Sáez JC, Kähne T, Gao FB, Berry JD, Nicholson K, Sena-Esteves M, Madrid R, Varela D, Montecino M, Brown RH, van Zundert B. Arredondo C, et al. Neuron. 2022 May 18;110(10):1656-1670.e12. doi: 10.1016/j.neuron.2022.02.010. Epub 2022 Mar 10. Neuron. 2022. PMID: 35276083 Free PMC article.
Mature iPSC-derived astrocytes of an ALS/FTD patient carrying the TDP43A90V mutation display a mild reactive state and release polyP toxic to motoneurons.
Rojas F, Aguilar R, Almeida S, Fritz E, Corvalán D, Ampuero E, Abarzúa S, Garcés P, Amaro A, Diaz I, Arredondo C, Cortes N, Sanchez M, Mercado C, Varela-Nallar L, Gao FB, Montecino M, van Zundert B. Rojas F, et al. Among authors: arredondo c. Front Cell Dev Biol. 2023 Jul 28;11:1226604. doi: 10.3389/fcell.2023.1226604. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 37645251 Free PMC article.
Ceramide-induced formation of ROS and ATP depletion trigger necrosis in lymphoid cells.
Villena J, Henriquez M, Torres V, Moraga F, Díaz-Elizondo J, Arredondo C, Chiong M, Olea-Azar C, Stutzin A, Lavandero S, Quest AF. Villena J, et al. Among authors: arredondo c. Free Radic Biol Med. 2008 Mar 15;44(6):1146-60. doi: 10.1016/j.freeradbiomed.2007.12.017. Epub 2007 Dec 23. Free Radic Biol Med. 2008. PMID: 18191646
The nuclear receptor NR4A1 is regulated by SUMO modification to induce autophagic cell death.
Zárraga-Granados G, Muciño-Hernández G, Sánchez-Carbente MR, Villamizar-Gálvez W, Peñas-Rincón A, Arredondo C, Andrés ME, Wood C, Covarrubias L, Castro-Obregón S. Zárraga-Granados G, et al. Among authors: arredondo c. PLoS One. 2020 Mar 25;15(3):e0222072. doi: 10.1371/journal.pone.0222072. eCollection 2020. PLoS One. 2020. PMID: 32210435 Free PMC article.
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