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Anti-inflammatory role demonstrated both in vitro and in vivo models using nonsteroidal tetranortriterpenoid, Nimbin (N1) and its analogs (N2 and N3) that alleviate the domestication of alternative medicine.
Sudhakaran G, Prathap P, Guru A, Rajesh R, Sathish S, Madhavan T, Arasu MV, Al-Dhabi NA, Choi KC, Gopinath P, Arockiaraj J. Sudhakaran G, et al. Among authors: arockiaraj j. Cell Biol Int. 2022 May;46(5):771-791. doi: 10.1002/cbin.11769. Epub 2022 Feb 3. Cell Biol Int. 2022. PMID: 35077598
Amelioration of acrylamide induced neurotoxicity by benzo[b]thiophene analogs via glutathione redox dynamics in zebrafish larvae.
Haridevamuthu B, Manjunathan T, Guru A, Ranjith Wilson Alphonse C, Boopathi S, Murugan R, Gatasheh MK, Atef Hatamleh A, Juliet A, Gopinath P, Arockiaraj J. Haridevamuthu B, et al. Among authors: arockiaraj j. Brain Res. 2022 Aug 1;1788:147941. doi: 10.1016/j.brainres.2022.147941. Epub 2022 May 10. Brain Res. 2022. PMID: 35550141
Reverse pharmacology of Nimbin-N2 attenuates alcoholic liver injury and promotes the hepatoprotective dual role of improving lipid metabolism and downregulating the levels of inflammatory cytokines in zebrafish larval model.
Sudhakaran G, Prathap P, Guru A, Haridevamuthu B, Murugan R, Almutairi BO, Almutairi MH, Juliet A, Gopinath P, Arockiaraj J. Sudhakaran G, et al. Among authors: arockiaraj j. Mol Cell Biochem. 2022 Oct;477(10):2387-2401. doi: 10.1007/s11010-022-04448-7. Epub 2022 May 16. Mol Cell Biochem. 2022. PMID: 35575874
Deacetylepoxyazadiradione Derived from Epoxyazadiradione of Neem (Azadirachta indica A. Juss) Fruits Mitigates LPS-Induced Oxidative Stress and Inflammation in Zebrafish Larvae.
Murugan R, Rajesh R, Guru A, Haridevamuthu B, Almutairi BO, Almutairi MH, Juliet A, Renganayagi S, Gopinath P, Arockiaraj J. Murugan R, et al. Among authors: arockiaraj j. Chem Biodivers. 2022 Sep;19(9):e202200041. doi: 10.1002/cbdv.202200041. Epub 2022 Aug 26. Chem Biodivers. 2022. PMID: 36026548
229 results