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Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-κB-driven inflammation and cardiovascular risk.
Zannas AS, Jia M, Hafner K, Baumert J, Wiechmann T, Pape JC, Arloth J, Ködel M, Martinelli S, Roitman M, Röh S, Haehle A, Emeny RT, Iurato S, Carrillo-Roa T, Lahti J, Räikkönen K, Eriksson JG, Drake AJ, Waldenberger M, Wahl S, Kunze S, Lucae S, Bradley B, Gieger C, Hausch F, Smith AK, Ressler KJ, Müller-Myhsok B, Ladwig KH, Rein T, Gassen NC, Binder EB. Zannas AS, et al. Among authors: arloth j. Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11370-11379. doi: 10.1073/pnas.1816847116. Epub 2019 May 21. Proc Natl Acad Sci U S A. 2019. PMID: 31113877 Free PMC article.
Dexamethasone stimulated gene expression in peripheral blood is a sensitive marker for glucocorticoid receptor resistance in depressed patients.
Menke A, Arloth J, Pütz B, Weber P, Klengel T, Mehta D, Gonik M, Rex-Haffner M, Rubel J, Uhr M, Lucae S, Deussing JM, Müller-Myhsok B, Holsboer F, Binder EB. Menke A, et al. Among authors: arloth j. Neuropsychopharmacology. 2012 May;37(6):1455-64. doi: 10.1038/npp.2011.331. Epub 2012 Jan 11. Neuropsychopharmacology. 2012. PMID: 22237309 Free PMC article.
Rare variants in TMEM132D in a case-control sample for panic disorder.
Quast C, Altmann A, Weber P, Arloth J, Bader D, Heck A, Pfister H, Müller-Myhsok B, Erhardt A, Binder EB. Quast C, et al. Among authors: arloth j. Am J Med Genet B Neuropsychiatr Genet. 2012 Dec;159B(8):896-907. doi: 10.1002/ajmg.b.32096. Epub 2012 Aug 22. Am J Med Genet B Neuropsychiatr Genet. 2012. PMID: 22911938
Functional coding variants in SLC6A15, a possible risk gene for major depression.
Quast C, Cuboni S, Bader D, Altmann A, Weber P, Arloth J, Röh S, Brückl T, Ising M, Kopczak A, Erhardt A, Hausch F, Lucae S, Binder EB. Quast C, et al. Among authors: arloth j. PLoS One. 2013 Jul 16;8(7):e68645. doi: 10.1371/journal.pone.0068645. Print 2013. PLoS One. 2013. PMID: 23874702 Free PMC article.
A polymorphism in the Crhr1 gene determines stress vulnerability in male mice.
Labermaier C, Kohl C, Hartmann J, Devigny C, Altmann A, Weber P, Arloth J, Quast C, Wagner KV, Scharf SH, Czibere L, Widner-Andrä R, Brenndörfer J, Landgraf R, Hausch F, Jones KA, Müller MB, Uhr M, Holsboer F, Binder EB, Schmidt MV. Labermaier C, et al. Among authors: arloth j. Endocrinology. 2014 Jul;155(7):2500-10. doi: 10.1210/en.2013-1986. Epub 2014 Apr 28. Endocrinology. 2014. PMID: 24773341
An analysis of gene expression in PTSD implicates genes involved in the glucocorticoid receptor pathway and neural responses to stress.
Logue MW, Smith AK, Baldwin C, Wolf EJ, Guffanti G, Ratanatharathorn A, Stone A, Schichman SA, Humphries D, Binder EB, Arloth J, Menke A, Uddin M, Wildman D, Galea S, Aiello AE, Koenen KC, Miller MW. Logue MW, et al. Among authors: arloth j. Psychoneuroendocrinology. 2015 Jul;57:1-13. doi: 10.1016/j.psyneuen.2015.03.016. Epub 2015 Mar 24. Psychoneuroendocrinology. 2015. PMID: 25867994 Free PMC article.
Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders.
Arloth J, Bogdan R, Weber P, Frishman G, Menke A, Wagner KV, Balsevich G, Schmidt MV, Karbalai N, Czamara D, Altmann A, Trümbach D, Wurst W, Mehta D, Uhr M, Klengel T, Erhardt A, Carey CE, Conley ED; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC); Ruepp A, Müller-Myhsok B, Hariri AR, Binder EB; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium PGC. Arloth J, et al. Neuron. 2015 Jun 3;86(5):1189-202. doi: 10.1016/j.neuron.2015.05.034. Neuron. 2015. PMID: 26050039 Free PMC article.
Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling.
Zannas AS, Arloth J, Carrillo-Roa T, Iurato S, Röh S, Ressler KJ, Nemeroff CB, Smith AK, Bradley B, Heim C, Menke A, Lange JF, Brückl T, Ising M, Wray NR, Erhardt A, Binder EB, Mehta D. Zannas AS, et al. Among authors: arloth j. Genome Biol. 2015 Dec 17;16:266. doi: 10.1186/s13059-015-0828-5. Genome Biol. 2015. PMID: 26673150 Free PMC article.
34 results