Arkin M - Search Results

1

Artificial cysteine-lipases with high activity and altered catalytic mechanism created by laboratory evolution.

Cen Y, Singh W, Arkin M, Moody TS, Huang M, Zhou J, Wu Q, Reetz MT. Cen Y, et al. Among authors: arkin m. Nat Commun. 2019 Jul 19;10(1):3198. doi: 10.1038/s41467-019-11155-3. Nat Commun. 2019. PMID: 31324776 Free PMC article.

2

Light-Driven Kinetic Resolution of α-Functionalized Carboxylic Acids Enabled by an Engineered Fatty Acid Photodecarboxylase.

Xu J, Hu Y, Fan J, Arkin M, Li D, Peng Y, Xu W, Lin X, Wu Q. Xu J, et al. Among authors: arkin m. Angew Chem Int Ed Engl. 2019 Jun 17;58(25):8474-8478. doi: 10.1002/anie.201903165. Epub 2019 May 14. Angew Chem Int Ed Engl. 2019. PMID: 31033108

3

Molecular glues for protein-protein interactions: Progressing toward a new dream.

Konstantinidou M, Arkin MR. Konstantinidou M, et al. Among authors: arkin mr. Cell Chem Biol. 2024 Apr 25:S2451-9456(24)00130-2. doi: 10.1016/j.chembiol.2024.04.002. Online ahead of print. Cell Chem Biol. 2024. PMID: 38701786 Free article. Review.

4

A Top-Down Proteomic Assay to Evaluate KRAS4B-Compound Engagement.

D'Ippolito RA, Rabara D, Blanco MA, Alberico E, Drew MR, Ramakrishnan N, Sontan D, Widmeyer SRT, Scheidemantle GM, Messing S, Turner D, Arkin M, Maciag AE, Stephen AG, Esposito D, McCormick F, Nissley DV, DeHart CJ. D'Ippolito RA, et al. Among authors: arkin m. Anal Chem. 2024 Apr 2;96(13):5223-5231. doi: 10.1021/acs.analchem.3c05626. Epub 2024 Mar 18. Anal Chem. 2024. PMID: 38498381 Free PMC article.

5

Identifying ligands for the PHD1 finger of KDM5A through high-throughput screening.

Ortiz G, Longbotham JE, Qin SL, Zhang MY, Lee GM, Neitz RJ, Kelly MJS, Arkin MR, Fujimori DG. Ortiz G, et al. Among authors: arkin mr. RSC Chem Biol. 2023 Dec 18;5(3):209-215. doi: 10.1039/d3cb00214d. eCollection 2024 Mar 6. RSC Chem Biol. 2023. PMID: 38456036 Free PMC article.

6

An in vivo screening platform identifies senolytic compounds that target p16INK4a+ fibroblasts in lung fibrosis.

Lee JY, Reyes NS, Ravishankar S, Zhou M, Krasilnikov M, Ringler C, Pohan G, Wilson C, Ang KK, Wolters PJ, Tsukui T, Sheppard D, Arkin MR, Peng T. Lee JY, et al. Among authors: arkin mr. J Clin Invest. 2024 Mar 7;134(9):e173371. doi: 10.1172/JCI173371. J Clin Invest. 2024. PMID: 38451724 Free PMC article.

7

The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.

Braxton JR, Altobelli CR, Tucker MR, Tse E, Thwin AC, Arkin MR, Southworth DR. Braxton JR, et al. Among authors: arkin mr. Nat Struct Mol Biol. 2023 Dec;30(12):2009-2019. doi: 10.1038/s41594-023-01126-0. Epub 2023 Nov 9. Nat Struct Mol Biol. 2023. PMID: 37945741 Free PMC article.

8

Synthetic autophagy receptor.

Jiang Z, Kuo YH, Arkin MR. Jiang Z, et al. Among authors: arkin mr. Autophagy. 2024 Mar;20(3):701-703. doi: 10.1080/15548627.2023.2278954. Epub 2024 Feb 14. Autophagy. 2024. PMID: 37934826

9

Autophagy Receptor-Inspired Antibody-Fusion Proteins for Targeted Intracellular Degradation.

Jiang Z, Kuo YH, Arkin MR. Jiang Z, et al. Among authors: arkin mr. J Am Chem Soc. 2023 Nov 8;145(44):23939-23947. doi: 10.1021/jacs.3c05199. Epub 2023 Sep 25. J Am Chem Soc. 2023. PMID: 37748140 Free PMC article.

10

Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein-Protein Interaction from Nonselective Fragments.

Konstantinidou M, Visser EJ, Vandenboorn E, Chen S, Jaishankar P, Overmans M, Dutta S, Neitz RJ, Renslo AR, Ottmann C, Brunsveld L, Arkin MR. Konstantinidou M, et al. Among authors: arkin mr. J Am Chem Soc. 2023 Sep 20;145(37):20328-20343. doi: 10.1021/jacs.3c05161. Epub 2023 Sep 7. J Am Chem Soc. 2023. PMID: 37676236 Free PMC article.

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