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Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders.
Johmura Y, Yamanaka T, Omori S, Wang TW, Sugiura Y, Matsumoto M, Suzuki N, Kumamoto S, Yamaguchi K, Hatakeyama S, Takami T, Yamaguchi R, Shimizu E, Ikeda K, Okahashi N, Mikawa R, Suematsu M, Arita M, Sugimoto M, Nakayama KI, Furukawa Y, Imoto S, Nakanishi M. Johmura Y, et al. Among authors: arita m. Science. 2021 Jan 15;371(6526):265-270. doi: 10.1126/science.abb5916. Science. 2021. PMID: 33446552
Reduction of lipid accumulation rescues Bietti's crystalline dystrophy phenotypes.
Hata M, Ikeda HO, Iwai S, Iida Y, Gotoh N, Asaka I, Ikeda K, Isobe Y, Hori A, Nakagawa S, Yamato S, Arita M, Yoshimura N, Tsujikawa A. Hata M, et al. Among authors: arita m. Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3936-3941. doi: 10.1073/pnas.1717338115. Epub 2018 Mar 26. Proc Natl Acad Sci U S A. 2018. PMID: 29581279 Free PMC article.
Transomics analysis reveals allosteric and gene regulation axes for altered hepatic glucose-responsive metabolism in obesity.
Kokaji T, Hatano A, Ito Y, Yugi K, Eto M, Morita K, Ohno S, Fujii M, Hironaka KI, Egami R, Terakawa A, Tsuchiya T, Ozaki H, Inoue H, Uda S, Kubota H, Suzuki Y, Ikeda K, Arita M, Matsumoto M, Nakayama KI, Hirayama A, Soga T, Kuroda S. Kokaji T, et al. Among authors: arita m. Sci Signal. 2020 Dec 1;13(660):eaaz1236. doi: 10.1126/scisignal.aaz1236. Sci Signal. 2020. PMID: 33262292
1,087 results