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Page 1
Nrf2 controls iron homeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin.
Lim PJ, Duarte TL, Arezes J, Garcia-Santos D, Hamdi A, Pasricha SR, Armitage AE, Mehta H, Wideman S, Santos AG, Santos-Gonçalves A, Morovat A, Hughes JR, Soilleux E, Wang CY, Bayer AL, Klenerman P, Willberg CB, Hartley RC, Murphy MP, Babitt JL, Ponka P, Porto G, Drakesmith H. Lim PJ, et al. Among authors: arezes j. Nat Metab. 2019 May;1(5):519-531. doi: 10.1038/s42255-019-0063-6. Epub 2019 May 13. Nat Metab. 2019. PMID: 31276102 Free PMC article.
Hepcidin is regulated by promoter-associated histone acetylation and HDAC3.
Pasricha SR, Lim PJ, Duarte TL, Casu C, Oosterhuis D, Mleczko-Sanecka K, Suciu M, Da Silva AR, Al-Hourani K, Arezes J, McHugh K, Gooding S, Frost JN, Wray K, Santos A, Porto G, Repapi E, Gray N, Draper SJ, Ashley N, Soilleux E, Olinga P, Muckenthaler MU, Hughes JR, Rivella S, Milne TA, Armitage AE, Drakesmith H. Pasricha SR, et al. Among authors: arezes j. Nat Commun. 2017 Sep 1;8(1):403. doi: 10.1038/s41467-017-00500-z. Nat Commun. 2017. PMID: 28864822 Free PMC article.
Erythroferrone inhibits the induction of hepcidin by BMP6.
Arezes J, Foy N, McHugh K, Sawant A, Quinkert D, Terraube V, Brinth A, Tam M, LaVallie ER, Taylor S, Armitage AE, Pasricha SR, Cunningham O, Lambert M, Draper SJ, Jasuja R, Drakesmith H. Arezes J, et al. Blood. 2018 Oct 4;132(14):1473-1477. doi: 10.1182/blood-2018-06-857995. Epub 2018 Aug 10. Blood. 2018. PMID: 30097509 Free PMC article.
Antiviral activity of bone morphogenetic proteins and activins.
Eddowes LA, Al-Hourani K, Ramamurthy N, Frankish J, Baddock HT, Sandor C, Ryan JD, Fusco DN, Arezes J, Giannoulatou E, Boninsegna S, Chevaliez S, Owens BMJ, Sun CC, Fabris P, Giordani MT, Martines D, Vukicevic S, Crowe J, Lin HY, Rehwinkel J, McHugh PJ, Binder M, Babitt JL, Chung RT, Lawless MW, Armitage AE, Webber C, Klenerman P, Drakesmith H. Eddowes LA, et al. Among authors: arezes j. Nat Microbiol. 2019 Feb;4(2):339-351. doi: 10.1038/s41564-018-0301-9. Epub 2018 Dec 3. Nat Microbiol. 2019. PMID: 30510168 Free PMC article.
Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease.
Gooding S, Olechnowicz SWZ, Morris EV, Armitage AE, Arezes J, Frost J, Repapi E, Edwards JR, Ashley N, Waugh C, Gray N, Martinez-Hackert E, Lim PJ, Pasricha SR, Knowles H, Mead AJ, Ramasamy K, Drakesmith H, Edwards CM. Gooding S, et al. Among authors: arezes j. Nat Commun. 2019 Oct 4;10(1):4533. doi: 10.1038/s41467-019-12296-1. Nat Commun. 2019. PMID: 31586071 Free PMC article.
Hepcidin-Mediated Hypoferremia Disrupts Immune Responses to Vaccination and Infection.
Frost JN, Tan TK, Abbas M, Wideman SK, Bonadonna M, Stoffel NU, Wray K, Kronsteiner B, Smits G, Campagna DR, Duarte TL, Lopes JM, Shah A, Armitage AE, Arezes J, Lim PJ, Preston AE, Ahern D, Teh M, Naylor C, Salio M, Gileadi U, Andrews SC, Dunachie SJ, Zimmermann MB, van der Klis FRM, Cerundolo V, Bannard O, Draper SJ, Townsend ARM, Galy B, Fleming MD, Lewis MC, Drakesmith H. Frost JN, et al. Among authors: arezes j. Med. 2021 Feb 12;2(2):164-179.e12. doi: 10.1016/j.medj.2020.10.004. Med. 2021. PMID: 33665641 Free PMC article.
Physiological implications of NTBI uptake by T lymphocytes.
Pinto JP, Arezes J, Dias V, Oliveira S, Vieira I, Costa M, Vos M, Carlsson A, Rikers Y, Rangel M, Porto G. Pinto JP, et al. Among authors: arezes j. Front Pharmacol. 2014 Feb 26;5:24. doi: 10.3389/fphar.2014.00024. eCollection 2014. Front Pharmacol. 2014. PMID: 24616700 Free PMC article.
12 results