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An inhaled ACE2 decoy confers protection against SARS-CoV-2 infection in preclinical models.
Urano E, Itoh Y, Suzuki T, Sasaki T, Kishikawa JI, Akamatsu K, Higuchi Y, Sakai Y, Okamura T, Mitoma S, Sugihara F, Takada A, Kimura M, Nakao S, Hirose M, Sasaki T, Koketsu R, Tsuji S, Yanagida S, Shioda T, Hara E, Matoba S, Matsuura Y, Kanda Y, Arase H, Okada M, Takagi J, Kato T, Hoshino A, Yasutomi Y, Saito A, Okamoto T. Urano E, et al. Among authors: arase h. Sci Transl Med. 2023 Aug 30;15(711):eadi2623. doi: 10.1126/scitranslmed.adi2623. Epub 2023 Aug 30. Sci Transl Med. 2023. PMID: 37647387
An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies.
Liu Y, Soh WT, Kishikawa JI, Hirose M, Nakayama EE, Li S, Sasai M, Suzuki T, Tada A, Arakawa A, Matsuoka S, Akamatsu K, Matsuda M, Ono C, Torii S, Kishida K, Jin H, Nakai W, Arase N, Nakagawa A, Matsumoto M, Nakazaki Y, Shindo Y, Kohyama M, Tomii K, Ohmura K, Ohshima S, Okamoto T, Yamamoto M, Nakagami H, Matsuura Y, Nakagawa A, Kato T, Okada M, Standley DM, Shioda T, Arase H. Liu Y, et al. Among authors: arase n, arase h. Cell. 2021 Jun 24;184(13):3452-3466.e18. doi: 10.1016/j.cell.2021.05.032. Epub 2021 May 24. Cell. 2021. PMID: 34139176 Free PMC article.
Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients.
Lu X, Hosono Y, Nagae M, Ishizuka S, Ishikawa E, Motooka D, Ozaki Y, Sax N, Maeda Y, Kato Y, Morita T, Shinnakasu R, Inoue T, Onodera T, Matsumura T, Shinkai M, Sato T, Nakamura S, Mori S, Kanda T, Nakayama EE, Shioda T, Kurosaki T, Takeda K, Kumanogoh A, Arase H, Nakagami H, Yamashita K, Takahashi Y, Yamasaki S. Lu X, et al. Among authors: arase h. J Exp Med. 2021 Dec 6;218(12):e20211327. doi: 10.1084/jem.20211327. Epub 2021 Oct 14. J Exp Med. 2021. PMID: 34647971 Free PMC article.
The SARS-CoV-2 Lambda variant exhibits enhanced infectivity and immune resistance.
Kimura I, Kosugi Y, Wu J, Zahradnik J, Yamasoba D, Butlertanaka EP, Tanaka YL, Uriu K, Liu Y, Morizako N, Shirakawa K, Kazuma Y, Nomura R, Horisawa Y, Tokunaga K, Ueno T, Takaori-Kondo A, Schreiber G, Arase H; Genotype to Phenotype Japan (G2P-Japan) Consortium; Motozono C, Saito A, Nakagawa S, Sato K. Kimura I, et al. Among authors: arase h. Cell Rep. 2022 Jan 11;38(2):110218. doi: 10.1016/j.celrep.2021.110218. Epub 2021 Dec 18. Cell Rep. 2022. PMID: 34968415 Free PMC article.
Serum autoantibodies against the extracellular region of α6β4 integrin in a patient with dipeptidyl peptidase-4 inhibitor-induced bullous pemphigoid.
Yamashita C, Arase N, Higuchi S, Arase H, Takagi J, Nojima S, Tanemura A, Fujimoto M. Yamashita C, et al. Among authors: arase n, arase h. JAAD Case Rep. 2021 Dec 23;20:65-68. doi: 10.1016/j.jdcr.2021.12.021. eCollection 2022 Feb. JAAD Case Rep. 2021. PMID: 35111892 Free PMC article. No abstract available.
Preclinical study of a DNA vaccine targeting SARS-CoV-2.
Hayashi H, Sun J, Yanagida Y, Otera T, Kubota-Koketsu R, Shioda T, Ono C, Matsuura Y, Arase H, Yoshida S, Nakamaru R, Ju N, Ide R, Tenma A, Kawabata S, Ehara T, Sakaguchi M, Tomioka H, Shimamura M, Okamoto S, Amaishi Y, Chono H, Mineno J, Komatsuno T, Saito Y, Rakugi H, Morishita R, Nakagami H. Hayashi H, et al. Among authors: arase h. Curr Res Transl Med. 2022 Sep;70(4):103348. doi: 10.1016/j.retram.2022.103348. Epub 2022 Apr 20. Curr Res Transl Med. 2022. PMID: 35489099 Free PMC article.
SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies.
Ng KW, Faulkner N, Finsterbusch K, Wu M, Harvey R, Hussain S, Greco M, Liu Y, Kjaer S, Swanton C, Gandhi S, Beale R, Gamblin SJ, Cherepanov P, McCauley J, Daniels R, Howell M, Arase H, Wack A, Bauer DLV, Kassiotis G. Ng KW, et al. Among authors: arase h. Sci Transl Med. 2022 Jul 27;14(655):eabn3715. doi: 10.1126/scitranslmed.abn3715. Epub 2022 Jul 27. Sci Transl Med. 2022. PMID: 35895836 Free article.
SARS-CoV-2 ORF8 is a viral cytokine regulating immune responses.
Kohyama M, Suzuki T, Nakai W, Ono C, Matsuoka S, Iwatani K, Liu Y, Sakai Y, Nakagawa A, Tomii K, Ohmura K, Okada M, Matsuura Y, Ohshima S, Maeda Y, Okamoto T, Arase H. Kohyama M, et al. Among authors: arase h. Int Immunol. 2023 Jan 21;35(1):43-52. doi: 10.1093/intimm/dxac044. Int Immunol. 2023. PMID: 36053553 Free PMC article.
218 results