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Genomewide CRISPR knockout screen identified PLAC8 as an essential factor for SADS-CoVs infection.
Tse LV, Meganck RM, Araba KC, Yount BL, Shaffer KM, Hou YJ, Munt JE, Adams LE, Wykoff JA, Morowitz JM, Dong S, Magness ST, Marzluff WF, Gonzalez LM, Ehre C, Baric RS. Tse LV, et al. Among authors: araba kc. Proc Natl Acad Sci U S A. 2022 May 3;119(18):e2118126119. doi: 10.1073/pnas.2118126119. Epub 2022 Apr 27. Proc Natl Acad Sci U S A. 2022. PMID: 35476513 Free PMC article.
SARS-CoV-2 infection of airway cells causes intense viral and cell shedding, two spreading mechanisms affected by IL-13.
Morrison CB, Edwards CE, Shaffer KM, Araba KC, Wykoff JA, Williams DR, Asakura T, Dang H, Morton LC, Gilmore RC, O'Neal WK, Boucher RC, Baric RS, Ehre C. Morrison CB, et al. Among authors: araba kc. Proc Natl Acad Sci U S A. 2022 Apr 19;119(16):e2119680119. doi: 10.1073/pnas.2119680119. Epub 2022 Mar 30. Proc Natl Acad Sci U S A. 2022. PMID: 35353667 Free PMC article.
Treatment of cystic fibrosis airway cells with CFTR modulators reverses aberrant mucus properties via hydration.
Morrison CB, Shaffer KM, Araba KC, Markovetz MR, Wykoff JA, Quinney NL, Hao S, Delion MF, Flen AL, Morton LC, Liao J, Hill DB, Drumm ML, O'Neal WK, Kesimer M, Gentzsch M, Ehre C. Morrison CB, et al. Among authors: araba kc. Eur Respir J. 2022 Feb 3;59(2):2100185. doi: 10.1183/13993003.00185-2021. Print 2022 Feb. Eur Respir J. 2022. PMID: 34172469 Free PMC article.
Increased colonic expression of ACE2 associates with poor prognosis in Crohn's disease.
Toyonaga T, Araba KC, Kennedy MM, Keith BP, Wolber EA, Beasley C, Steinbach EC, Schaner MR, Jain A, Long MD, Barnes EL, Herfarth HH, Isaacs KL, Hansen JJ, Kapadia MR, Guillem JG, Gulati AS, Sethupathy P, Furey TS, Ehre C, Sheikh SZ. Toyonaga T, et al. Among authors: araba kc. Sci Rep. 2021 Jun 29;11(1):13533. doi: 10.1038/s41598-021-92979-2. Sci Rep. 2021. PMID: 34188154 Free PMC article.
Increased Colonic Expression of ACE2 Associates with Poor Prognosis in Crohn's disease.
Toyonaga T, Araba KC, Kennedy MM, Keith BP, Wolber EA, Beasley C, Steinbach EC, Schaner MR, Jain A, Long MD, Barnes EL, Herfarth HH, Isaacs KL, Hansen JJ, Kapadia M, Gaston Guillem J, Koruda MJ, Rahbar R, Sadiq T, Gulati AS, Sethupathy P, Furey TS, Ehre C, Sheikh SZ. Toyonaga T, et al. Among authors: araba kc. bioRxiv [Preprint]. 2020 Nov 24:2020.11.24.396382. doi: 10.1101/2020.11.24.396382. bioRxiv. 2020. PMID: 33269348 Free PMC article. Updated. Preprint.