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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1962 1
1964 4
1965 1
1966 2
1967 1
1968 1
1970 1
1971 1
1972 2
1973 4
1974 11
1975 41
1976 70
1977 97
1978 63
1979 101
1980 94
1981 84
1982 110
1983 127
1984 118
1985 86
1986 112
1987 75
1988 75
1989 66
1990 77
1991 79
1992 72
1993 89
1994 96
1995 86
1996 100
1997 89
1998 87
1999 121
2000 130
2001 150
2002 152
2003 178
2004 179
2005 177
2006 167
2007 216
2008 209
2009 198
2010 219
2011 253
2012 223
2013 198
2014 213
2015 231
2016 177
2017 157
2018 162
2019 135
2020 158
2021 140
2022 94
2023 52
2024 30

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5,825 results

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Page 1
Fludarabine: a review.
Hood MA, Finley RS. Hood MA, et al. DICP. 1991 May;25(5):518-24. doi: 10.1177/106002809102500512. DICP. 1991. PMID: 2068837 Review.
Cytarabine is used principally as an antileukemic agent, and vidarabine as an antiviral. Unlike vidarabine, fludarabine is resistant to deactivation by adenosine deaminase. ...
Cytarabine is used principally as an antileukemic agent, and vidarabine as an antiviral. Unlike vidarabine, fludarabine is res …
Therapy with 9-beta-D-arabinofuranosyladenine (ARA-A) and 2'-deoxycoformycin increases the ARA-A content of ocular tissues.
O'Brien WJ. O'Brien WJ. Curr Eye Res. 1986 Aug;5(8):595-9. doi: 10.3109/02713688609015124. Curr Eye Res. 1986. PMID: 3489583
The amount of 9-beta-D-arabinofuranosyladenine (ARA-A) and 9-beta-D-arabinofuranosylhypoxanthine (ARA-Hx) present in ocular tissues of rabbits was determined following therapy with ARA-A alone and when ARA-A was used in combination with 2 …
The amount of 9-beta-D-arabinofuranosyladenine (ARA-A) and 9-beta-D-arabinofuranosylhypoxanthine (ARA-Hx) present in ocular ti …
Pharmacokinetics of 2-F-ara-A (9-beta-D-arabinofuranosyl-2-fluoroadenine) in cancer patients during the phase I clinical investigation of fludarabine phosphate.
Malspeis L, Grever MR, Staubus AE, Young D. Malspeis L, et al. Semin Oncol. 1990 Oct;17(5 Suppl 8):18-32. Semin Oncol. 1990. PMID: 1699279
(fludarabine phosphate) (2-F-ara-adenosine monophosphate [2-F-ara-AMP], NSC 312887) is the 5'-phosphate of 2-F-ara-A-(9-beta-D-arabinofuranosyl-2-fluoroadenine), a derivative of ara-A that is resistant to deamination and selectively inhibits DNA synthe …
(fludarabine phosphate) (2-F-ara-adenosine monophosphate [2-F-ara-AMP], NSC 312887) is the 5'-phosphate of 2-F-ara-A-(9-beta-D …
Vidarabine is neither a potent nor a selective AC5 inhibitor.
Seifert R. Seifert R. Biochem Pharmacol. 2014 Feb 15;87(4):543-6. doi: 10.1016/j.bcp.2013.12.025. Epub 2014 Jan 4. Biochem Pharmacol. 2014. PMID: 24398424 Review.
Therefore, vidarabine has been suggested to mediate these effects via selective inhibition of AC5. ...Here, evidence is presented that vidarabine is neither a potent nor a selective AC5 inhibitor. Greatest caution should be exerted when proposing new mechanisms of a …
Therefore, vidarabine has been suggested to mediate these effects via selective inhibition of AC5. ...Here, evidence is presented tha …
5'-O-D-valyl ara A, a potential prodrug for improving oral bioavailability of the antiviral agent vidarabine.
Shen W, Kim JS, Mitchell S, Kish P, Kijek P, Hilfinger J. Shen W, et al. Nucleosides Nucleotides Nucleic Acids. 2009;28(1):43-55. doi: 10.1080/15257770802581757. Nucleosides Nucleotides Nucleic Acids. 2009. PMID: 19116869 Free PMC article.
In order to improve the oral bioavailability of Adenine 9-beta-D-arabinofuranoside (Vidarabine, also called ara A), an antiviral drug which is active against herpes simplex and varicella zoster viruses and the first agent to be licensed for the treatment of s …
In order to improve the oral bioavailability of Adenine 9-beta-D-arabinofuranoside (Vidarabine, also called ara A), an …
F-ara-A pharmacokinetics during reduced-intensity conditioning therapy with fludarabine and busulfan.
Bonin M, Pursche S, Bergeman T, Leopold T, Illmer T, Ehninger G, Schleyer E, Bornhauser M. Bonin M, et al. Bone Marrow Transplant. 2007 Feb;39(4):201-6. doi: 10.1038/sj.bmt.1705565. Epub 2007 Jan 8. Bone Marrow Transplant. 2007. PMID: 17211431 Clinical Trial.
So far, no data are available on busulfan-fludarabine drug interactions in transplant recipients. The pharmacokinetic (PK) properties of F-ara-A (9-beta-D-arabinosyl-2-fluoradenine) before and after application of busulfan were prospectively investigated in 16 patie …
So far, no data are available on busulfan-fludarabine drug interactions in transplant recipients. The pharmacokinetic (PK) properties of F- …
Synthesis, biotransformation, and pharmacokinetic studies of 9-(beta-D-arabinofuranosyl)-6-azidopurine: a prodrug for ara-A designed to utilize the azide reduction pathway.
Kotra LP, Manouilov KK, Cretton-Scott E, Sommadossi JP, Boudinot FD, Schinazi RF, Chu CK. Kotra LP, et al. J Med Chem. 1996 Dec 20;39(26):5202-7. doi: 10.1021/jm960339p. J Med Chem. 1996. PMID: 8978848
The in vivo metabolism and disposition of ara-A and 6-AAP were conducted in mice. When 6-AAP was administered by either oral or intravenous route,the half-life of ara-A was 7-14 times higher than for ara-A administered intravenously. A …
The in vivo metabolism and disposition of ara-A and 6-AAP were conducted in mice. When 6-AAP was administered by either oral o …
A phase I/II study of idarubicin (Ida) with continuous infusion fludarabine (F-ara-A) and cytarabine (ara-C) for refractory or recurrent pediatric acute myeloid leukemia (AML).
Leahey A, Kelly K, Rorke LB, Lange B. Leahey A, et al. J Pediatr Hematol Oncol. 1997 Jul-Aug;19(4):304-8. doi: 10.1097/00043426-199707000-00007. J Pediatr Hematol Oncol. 1997. PMID: 9256828 Clinical Trial.
As phase I safety was documented by CCG, we increased the dose of Ida given on day 0, 1, and 2 of the F-ara-A/ara-C infusion (F-ara-A: 10.5 mg/m2 over 15 minutes and 1.27 mg/m2/hour for 48 hours followed by ara-C: 390 mg/m2 over 15 minutes and 101 mg/m …
As phase I safety was documented by CCG, we increased the dose of Ida given on day 0, 1, and 2 of the F-ara-A/ara-C infusion ( …
Simultaneous quantification of busulfan, clofarabine and F-ARA-A using isotope labelled standards and standard addition in plasma by LC-MS/MS for exposure monitoring in hematopoietic cell transplantation conditioning.
Punt AM, Langenhorst JB, Egas AC, Boelens JJ, van Kesteren C, van Maarseveen EM. Punt AM, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jun 15;1055-1056:81-85. doi: 10.1016/j.jchromb.2017.04.025. Epub 2017 Apr 15. J Chromatogr B Analyt Technol Biomed Life Sci. 2017. PMID: 28445850 Free article.
However, when SILS are unavailable (in case of Clo and F-ARA-A) or very expensive, standard addition may serve as an alternative to correct for recovery and matrix effects. ...Comparison of Bu, Clo and F-ARA-A standard addition results correspond with …
However, when SILS are unavailable (in case of Clo and F-ARA-A) or very expensive, standard addition may serve as an alternati …
Dialysate concentration and pharmacokinetics of 2F-Ara-A in a patient with acute renal failure.
Kielstein JT, Stadler M, Czock D, Keller F, Hertenstein B, Radermacher J. Kielstein JT, et al. Eur J Haematol. 2005 Jun;74(6):533-4. doi: 10.1111/j.1600-0609.2005.00439.x. Eur J Haematol. 2005. PMID: 15876260
The total body clearance of the principal metabolite 2-fluoro-ara-A (2F-Ara-A) correlates with the creatinine clearance. We report data on total dialysate concentration as well as pharmacokinetics of 2F-Ara-A in a patient with anuric acut …
The total body clearance of the principal metabolite 2-fluoro-ara-A (2F-Ara-A) correlates with the creatinine cl …
5,825 results