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Multi-cellular 3D human primary liver cell culture elevates metabolic activity under fluidic flow.
Lab Chip. 2015 May 21;15(10):2269-77. doi: 10.1039/c5lc00237k.
Lab Chip. 2015.
PMID: 25857666
Free PMC article.
Modular, pumpless body-on-a-chip platform for the co-culture of GI tract epithelium and 3D primary liver tissue.
Esch MB, Ueno H, Applegate DR, Shuler ML.
Esch MB, et al. Among authors: applegate dr.
Lab Chip. 2016 Jul 5;16(14):2719-29. doi: 10.1039/c6lc00461j.
Lab Chip. 2016.
PMID: 27332143
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A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity.
Kostadinova R, Boess F, Applegate D, Suter L, Weiser T, Singer T, Naughton B, Roth A.
Kostadinova R, et al.
Toxicol Appl Pharmacol. 2013 Apr 1;268(1):1-16. doi: 10.1016/j.taap.2013.01.012. Epub 2013 Jan 23.
Toxicol Appl Pharmacol. 2013.
PMID: 23352505
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Screening a mouse liver gene expression compendium identifies modulators of the aryl hydrocarbon receptor (AhR).
Oshida K, Vasani N, Thomas RS, Applegate D, Gonzalez FJ, Aleksunes LM, Klaassen CD, Corton JC.
Oshida K, et al.
Toxicology. 2015 Oct 2;336:99-112. doi: 10.1016/j.tox.2015.07.005. Epub 2015 Jul 26.
Toxicology. 2015.
PMID: 26215100
Free PMC article.
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Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor α (PPARα) in a mouse liver gene expression compendium.
Oshida K, Vasani N, Thomas RS, Applegate D, Rosen M, Abbott B, Lau C, Guo G, Aleksunes LM, Klaassen C, Corton JC.
Oshida K, et al.
PLoS One. 2015 Feb 17;10(2):e0112655. doi: 10.1371/journal.pone.0112655. eCollection 2015.
PLoS One. 2015.
PMID: 25689681
Free PMC article.
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Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendium.
Oshida K, Vasani N, Jones C, Moore T, Hester S, Nesnow S, Auerbach S, Geter DR, Aleksunes LM, Thomas RS, Applegate D, Klaassen CD, Corton JC.
Oshida K, et al. Among authors: applegate d.
Nucl Recept Signal. 2015 Apr 27;13:e002. doi: 10.1621/nrs.13002. eCollection 2015.
Nucl Recept Signal. 2015.
PMID: 25949234
Free PMC article.
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Advance Tissue Sciences, Inc. Interview by Semahat S Demir.
Applegate DR.
Applegate DR.
IEEE Eng Med Biol Mag. 2002 Nov-Dec;21(6):29-31.
IEEE Eng Med Biol Mag. 2002.
PMID: 12613206
No abstract available.
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