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Modifications at C(5) of 2-(2-Pyrrolidinyl)-Substituted 1,4-Benzodioxane Elicit Potent α4β2 Nicotinic Acetylcholine Receptor Partial Agonism with High Selectivity over the α3β4 Subtype.
Bavo F, Pallavicini M, Gotti C, Appiani R, Moretti M, Colombo SF, Pucci S, Viani P, Budriesi R, Renzi M, Fucile S, Bolchi C. Bavo F, et al. Among authors: appiani r. J Med Chem. 2020 Dec 24;63(24):15668-15692. doi: 10.1021/acs.jmedchem.0c01150. Epub 2020 Dec 16. J Med Chem. 2020. PMID: 33325696 Free article.
From 2-Triethylammonium Ethyl Ether of 4-Stilbenol (MG624) to Selective Small-Molecule Antagonists of Human α9α10 Nicotinic Receptor by Modifications at the Ammonium Ethyl Residue.
Bavo F, Pallavicini M, Pucci S, Appiani R, Giraudo A, Eaton B, Lucero L, Gotti C, Moretti M, Whiteaker P, Bolchi C. Bavo F, et al. Among authors: appiani r. J Med Chem. 2022 Jul 28;65(14):10079-10097. doi: 10.1021/acs.jmedchem.2c00746. Epub 2022 Jul 14. J Med Chem. 2022. PMID: 35834819 Free PMC article.
Behavioural and pharmacological profiles of zebrafish administrated pyrrolidinyl benzodioxanes and prolinol aryl ethers with high affinity for heteromeric nicotinic acetylcholine receptors.
Braida D, Ponzoni L, Moretti M, Viani P, Pallavicini M, Bolchi C, Appiani R, Bavo F, Gotti C, Sala M. Braida D, et al. Among authors: appiani r. Psychopharmacology (Berl). 2020 Aug;237(8):2317-2326. doi: 10.1007/s00213-020-05536-6. Epub 2020 May 7. Psychopharmacology (Berl). 2020. PMID: 32382782 Free article.
Green Oxidation of Ketones to Lactones with Oxone in Water.
Bertolini V, Appiani R, Pallavicini M, Bolchi C. Bertolini V, et al. Among authors: appiani r. J Org Chem. 2021 Nov 5;86(21):15712-15716. doi: 10.1021/acs.joc.1c01469. Epub 2021 Oct 13. J Org Chem. 2021. PMID: 34643386 Free article.
Subnanomolar Affinity and Selective Antagonism at α7 Nicotinic Receptor by Combined Modifications of 2-Triethylammonium Ethyl Ether of 4-Stilbenol (MG624).
Bavo F, Pallavicini M, Pucci S, Appiani R, Giraudo A, Oh H, Kneisley DL, Eaton B, Lucero L, Gotti C, Clementi F, Whiteaker P, Bolchi C. Bavo F, et al. Among authors: appiani r. J Med Chem. 2023 Jan 12;66(1):306-332. doi: 10.1021/acs.jmedchem.2c01256. Epub 2022 Dec 16. J Med Chem. 2023. PMID: 36526469 Free PMC article.